TO ASSESS THE EFFICACY OF PARAVERTEBRAL BLOCK AND INTERCOSTAL NERVE BLOCK FOR THORACIC HERPES ZOSTER : RANDOMIZED COMPARATIVE STUDY
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- NIDHI CHINCHOLI
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- decrease in NRS score post block for herpes zoster
Overview
Brief Summary
Study design & technique : Randomized Comparative Prospective study
Study duration : 18 months****Study design & technique : Randomized Comparative Prospective study
40 patients aged greater than 40 years of age of either gender with herpes zoster greater than 1 week since onset of rash, involving up to 2 thoracic dermatomes with Numerical rating score (NRS) greater than 4 who shall visit the pain clinic and fulfill the inclusion and exclusion criteria will be included . After taking their due consent ,patients will be randomized into 2 groups with 20 in each group using sealed opaque envelope techniquey duration : 18 months
Both the blocks will be performed under ultrasound guidance using a high frequency linear probe following strict aseptic precautions and using standard American Society of Anesthesiology monitoring
Group I – INTERCOSTAL NERVE BLOCK 2.5 mL bupivacaine 0.25% + 2 mg dexamethasone is injected for each level .
Group P :PARAVERTEBRAL BLOCK 15 ml of 0.25% Bupivacaine with 8 mg of Dexamethasone will be injected for into the thoracic paravertebral space .
Follow up: Pre procedure, immediate post procedure and at intervals of 2, 4, 12 and 24 weeks NRS,S - LANSS , SF 36 , complictions (if any ) and the incidence of Post herpetic neuralgia will be assessed
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 40.00 Year(s) to 90.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Age greater 40 years of age of either gender Herpes zoster greater 1 week since onset of rash HZ involving up to 2 thoracic dermatomes Numerical rating score (NRS)greater 4 Pain refractory to conservative management.
Exclusion Criteria
- •Infection at site of injection Patients with coagulopathy or on anticoagulants Patients on chemotherapy or immunosuppressive drugs Any contraindication to neuraxial injection Uncontrolled medical illness Hypersensitivity to LA Pregnancy and lactating women.
Outcomes
Primary Outcomes
decrease in NRS score post block for herpes zoster
Time Frame: decrease in pain NRS score post block for thoracic herpes zoster
Secondary Outcomes
- decrease in incidence of PHN(6 months)
Investigators
Nidhi Chincholi
JSS MEDICAL COLLEGE , mysore