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临床试验/CTRI/2026/01/101352
CTRI/2026/01/101352尚未招募不适用

TO ASSESS THE EFFICACY OF PARAVERTEBRAL BLOCK AND INTERCOSTAL NERVE BLOCK FOR THORACIC HERPES ZOSTER : RANDOMIZED COMPARATIVE STUDY

NIDHI CHINCHOLI1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2026年1月21日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
decrease in NRS score post block for herpes zoster

研究概览

简要总结

Study design & technique : Randomized Comparative  Prospective study

Study duration : 18 months****Study design & technique : Randomized Comparative  Prospective study

40  patients aged  greater than 40 years of age of either gender  with herpes zoster greater than 1 week since onset of rash, involving up to 2 thoracic dermatomes with Numerical rating score (NRS) greater than 4 who shall visit the pain clinic and fulfill the inclusion and exclusion criteria will be included . After taking their due consent ,patients will be randomized into 2 groups with 20  in each group using sealed opaque envelope techniquey duration : 18 months

Both the blocks will be performed under ultrasound guidance using a high frequency linear probe following  strict aseptic precautions and using standard American Society of Anesthesiology  monitoring

Group I – INTERCOSTAL NERVE BLOCK    2.5  mL bupivacaine 0.25% + 2 mg dexamethasone is injected for each level .

Group P :PARAVERTEBRAL BLOCK 15 ml of 0.25% Bupivacaine with 8 mg of Dexamethasone will be injected for   into the thoracic paravertebral space .

Follow up:  Pre procedure, immediate post procedure and at intervals of 2, 4, 12 and 24 weeks   NRS,S - LANSS , SF 36 , complictions (if any ) and the  incidence of  Post herpetic neuralgia will be assessed

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant and Investigator Blinded

入排标准

年龄范围
40.00 Year(s) 至 90.00 Year(s)(—)
性别
All

入选标准

  • Age greater 40 years of age of either gender Herpes zoster greater 1 week since onset of rash HZ involving up to 2 thoracic dermatomes Numerical rating score (NRS)greater 4 Pain refractory to conservative management.

排除标准

  • Infection at site of injection Patients with coagulopathy or on anticoagulants Patients on chemotherapy or immunosuppressive drugs Any contraindication to neuraxial injection Uncontrolled medical illness Hypersensitivity to LA Pregnancy and lactating women.

结局指标

主要结局

decrease in NRS score post block for herpes zoster

时间窗: decrease in pain NRS score post block for thoracic herpes zoster

次要结局

  • decrease in incidence of PHN(6 months)

研究者

发起方
NIDHI CHINCHOLI
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Nidhi Chincholi

JSS MEDICAL COLLEGE , mysore

研究点 (1)

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