TO ASSESS THE EFFICACY OF PARAVERTEBRAL BLOCK AND INTERCOSTAL NERVE BLOCK FOR THORACIC HERPES ZOSTER : RANDOMIZED COMPARATIVE STUDY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- decrease in NRS score post block for herpes zoster
研究概览
简要总结
Study design & technique : Randomized Comparative Prospective study
Study duration : 18 months****Study design & technique : Randomized Comparative Prospective study
40 patients aged greater than 40 years of age of either gender with herpes zoster greater than 1 week since onset of rash, involving up to 2 thoracic dermatomes with Numerical rating score (NRS) greater than 4 who shall visit the pain clinic and fulfill the inclusion and exclusion criteria will be included . After taking their due consent ,patients will be randomized into 2 groups with 20 in each group using sealed opaque envelope techniquey duration : 18 months
Both the blocks will be performed under ultrasound guidance using a high frequency linear probe following strict aseptic precautions and using standard American Society of Anesthesiology monitoring
Group I – INTERCOSTAL NERVE BLOCK 2.5 mL bupivacaine 0.25% + 2 mg dexamethasone is injected for each level .
Group P :PARAVERTEBRAL BLOCK 15 ml of 0.25% Bupivacaine with 8 mg of Dexamethasone will be injected for into the thoracic paravertebral space .
Follow up: Pre procedure, immediate post procedure and at intervals of 2, 4, 12 and 24 weeks NRS,S - LANSS , SF 36 , complictions (if any ) and the incidence of Post herpetic neuralgia will be assessed
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 40.00 Year(s) 至 90.00 Year(s)(—)
- 性别
- All
入选标准
- •Age greater 40 years of age of either gender Herpes zoster greater 1 week since onset of rash HZ involving up to 2 thoracic dermatomes Numerical rating score (NRS)greater 4 Pain refractory to conservative management.
排除标准
- •Infection at site of injection Patients with coagulopathy or on anticoagulants Patients on chemotherapy or immunosuppressive drugs Any contraindication to neuraxial injection Uncontrolled medical illness Hypersensitivity to LA Pregnancy and lactating women.
结局指标
主要结局
decrease in NRS score post block for herpes zoster
时间窗: decrease in pain NRS score post block for thoracic herpes zoster
次要结局
- decrease in incidence of PHN(6 months)
研究者
Nidhi Chincholi
JSS MEDICAL COLLEGE , mysore
