REspiratory Support in COPD after acUte Exacerbation.
Completed
- Conditions
- 1. COPD<br />2. Acute respiratory failure<br />3. Non-invasive ventilation.
- Registration Number
- NL-OMON25398
- Lead Sponsor
- niversity Medical Center Groningen (UMCG), Department of Pulmonology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
1. Chronic Obstructive pulmonary disease (COPD), GOLD severity stage 3 and 4;
2. Minimally 48 hours without ventilatory support after invasive or non invasive ventilatory support during an acute respiratory failure and maximally until discharge;
Exclusion Criteria
1. Age < 18 or =>75 years;
2. Significant bronchiectasis with recurrent infections;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to event is the primary study outcome, for which an event is defined as a readmission to hospital due to an exacerbation or death.
- Secondary Outcome Measures
Name Time Method 1. Exacerbations;<br /><br>2. Health related quality of life;<br /><br>3. Total readmission rate;<br /><br>4. Total event rate;<br /><br>5. Survival;<br /><br>6. Medical costs;<br /><br>7. Dyspnoea;<br /><br>8. Activities of daily living;<br /><br>9. Exercise tolerance;<br /><br>10. Blood gasses PaO2 and PaCo2;<br /><br>11. Lung function;<br /><br>12. Inflammation (systemic) markers*;<br /><br>13. Muscle strength*;<br /><br>14. Nutritional status*;<br /><br>* if possible in specialised centres.