Radiological Imaging in Patients Tested for COVID-19

Active, not recruiting

• Conditions: COVID-19; Cardiovascular Diseases; Coronary Artery Disease

• Registration Number: NCT05188443
• Lead Sponsor: University of Edinburgh

Brief Summary

It has become apparent that patients with co-morbidities have an increased risk of mortality from coronarvirus disease 2019 (COVID-19). However, the impact of subclinical respiratory and cardiovascular disease on the outcome of patients with COVID-19 is currently unknown. This observational study will assess the impact of incidental cardiovascular calcification on radiological imaging on the outcomes of patients with COVD-19.

Detailed Description

It has become apparent that patients with co-morbidities have an increased risk of mortality from coronarvirus disease 2019 (COVID-19). However, the impact of subclinical respiratory and cardiovascular disease on the outcome of patients with COVID-19 is currently unknown.

Subclinical respiratory and cardiovascular disease can be identified on radiological imaging. For example, calcification in blood vessels can identify cardiovascular disease, intra-thoracic and intra-abdominal fat is associated with coronary artery disease, and lung diseases can be identified on CT and x-ray. The impact these radiological features on the outcomes of patients with COVID-19 is currently unknown.

This study aims to assess the radiological imaging of patients tested for COVID-19 in order to identify the presence of co-existing respiratory and cardiovascular disease and assess their impact on clinical outcomes.

All patients tested for COVID-19 with current or previous (last 3 years) radiological imaging will be included in this study. Radiological images will be de-identified and assessed for the presence of cardiovascular calcification. Information on COVID-19 tests and clinical factors will be obtained from routinely collected data. Additional clinical information will be obtained from electronic health records as required.

Study Timeline

• Study Start: 2020-08-01
• Study First Submitted: 2022-01-05
• Study First Submitted QC: 2022-01-11
• Study First Posted: 2022-01-12
• Status Verified: 2023-06
• Primary Completion: 2023-07-01
• Last Update Submitted: 2024-05-22
• Last Update Posted: 2024-05-23
• Study Completion: 2024-07-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• One or more positive RT-PCR test for COVID-19.
• One or more CT or chest x-ray available performed within the last 3 years

Exclusion Criteria

• No available radiological imaging within the last 3 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All cause mortality	1 month	All cause mortality

Secondary Outcome Measures

Name	Time	Method
Cardiovascular mortality	1 month	Cardiovascular mortality

Trial Locations

Locations (1)

University of Edinburgh; 🇬🇧 Edinburgh, Scotland, United Kingdom