Priming the brain after stroke for a better response to arm training

Completed

• Conditions: Subcortical Stroke; Stroke - Ischaemic; Stroke - Haemorrhagic

• Registration Number: ACTRN12610000314022
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-04-20
• Study Completion: 2011-02-04
• Last Update Posted: 28 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

First-ever subcortical stroke
Upper-limb impairment

Exclusion Criteria

Neurological problem other than stroke
Cardiac pacemaker
Metal implants
Seizures
Certain types of medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Precision grip function (Preload force and duration) with a customised grip-lift manipulandum[Pre and post TBS- and training];Sensorimotor integration with % short-latency afferent inhibition (SAI).<br><br><br>SAI is assessed using transcranial magnetic stimulation (TMS) and peripheral nerve stimulation. Peripheral nerve stimulation will be delivered via a digitial electrode to the index finger of the contralateral hand. The stimulation intensity will be 2 - 3 times perceptual threshold. TMS will be delivered following peripheral stimulation, at an interstimulus interval determined for each individual (25,30 or 40ms). <br><br>The pairing of these stimuli results in inhibition of the motor evoked potential (MEP). The MEP is recorded using electromyography. The magnitude of inhibition after TBS and training will be compared to the inhibition recorded at baseline.[Pre and post TBS- and training];Change in Action Research Arm Test score[Pre and post intervention]

Secondary Outcome Measures

Name	Time	Method
Corticomotor excitability with transcranial magentic stimulation (TMS).<br><br><br>TMS will be delivered over ipsilesional and contralesional M1. Motor evoked potentials will be recorded using electromyography, with electrodes over the first doral interosseous bilaterally. Corticomotor excitability of ipsilesional and contralesional M1 will be determined by averaging contralateral MEP area over 16 stimuli to the affected (cMEPipsi) and non-affected (cMEPcontra) hands.[Pre and post TBS- and training]