Increased brain activation after painful stimulation of the forearm muscles in patients with fibromyalgia syndrome
Completed
- Conditions
- FibromyalgiaMusculoskeletal Diseases
- Registration Number
- ISRCTN15015327
- Lead Sponsor
- niversity of Würzburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
1. Aged 18 years or over
2. Patients with:
2.1. Fibromyalgia syndrome
2.2. Unipolar major depression (MD) without pain
2.3.Healthy controls
Exclusion Criteria
1. Other possible differential diagnoses (e.g. rheumatoid arthritis; post-surgery pain)
2. Current or prior cerebral disease (e.g. stroke, cerebral hemorrhage, head trauma)
3. Any clinically relevant psychiatric disorder (examined by systematic psychiatric interview)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Muscular pressure pain: fNIRS measurements were performed during the application of painful pressure on the muscle bulk of the finger extensors of the right side using a calibrated algesiometer. The stimulation conditions were as follows: pressure application for two seconds; pause for ten seconds between two stimuli; total of 40 stimuli, i.e. measurement at baseline and up to 8 minutes after first stimulation.
- Secondary Outcome Measures
Name Time Method Verbal fluency test (VFT): The VFT paradigm consisted of three conditions. Subjects were asked to produce as many different nouns as possible a) starting with a certain letter (A, F, and S), or b) belonging to the same category (animals, fruits, and flowers) or c) to name the days of the week as a control condition. Each condition lasted for 30 sec followed by 30 sec rest. Subjects worked on nine blocks in total (3 x letters, 3 x categories, 3 x week days), i.e. measurement at baseline and up to 9 minutes after start.