MedPath

Comparison of Escitalopram Combination in Adult Patients With Major Depressive Disorder

Phase 3
Completed
Conditions
Major Depressive Disorder
Registration Number
NCT00109044
Lead Sponsor
Forest Laboratories
Brief Summary

Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults. This study is designed to evaluate the efficacy and safety of a fixed-dose escitalopram combination relative to its component monotherapies and to placebo in patients with major depressive disorder.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
540
Inclusion Criteria
  • Patients must meet Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) diagnostic criteria for Major Depressive Disorder.
  • The patient's current depressive episode must be at least 12 weeks in duration.
Exclusion Criteria
  • Women who are pregnant, women who will be breastfeeding during the study, and women of childbearing potential who are not practicing a reliable method of birth control.
  • Patients who currently meet DSM-IV criteria for: a. bipolar disorder; b. schizophrenia or any psychotic disorder; c. obsessive-compulsive disorder; d. mental retardation or any pervasive developmental disorder or cognitive disorder.
  • Patients who are considered a suicide risk.
  • Patients with a history of seizure disorder, or any history of seizure, stroke, significant head injury, or any other condition that predisposes toward risk of seizure.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Montgomery Asberg Depression Rating Scale (MADRS)
Secondary Outcome Measures
NameTimeMethod
Hamilton Depression Rating Scale (HAMD)

Trial Locations

Locations (17)

Cunningham Clinical Research, LLC

🇺🇸

Edwardsville, Illinois, United States

Dominion Clinical Research

🇺🇸

Midlothian, Virginia, United States

Capital Clinical Research Associates

🇺🇸

Rockville, Maryland, United States

Piedmont Medical Research Associates, Inc.

🇺🇸

Winston-Salem, North Carolina, United States

Center for Emotional Fitness

🇺🇸

Moorestown, New Jersey, United States

Eastside Comprehensive Medical Center

🇺🇸

New York, New York, United States

Alpine Clinical Research

🇺🇸

Boulder, Colorado, United States

Southwest Health, Ltd

🇺🇸

Phoenix, Arizona, United States

Clinical Neuroscience Solutions, Inc.

🇺🇸

Memphis, Tennessee, United States

Radiant Research, Inc.

🇺🇸

Denver, Colorado, United States

Summit Research Network (Michigan), Inc.

🇺🇸

Okemos, Michigan, United States

Midwest Center for Neurobiological Medicine

🇺🇸

Oakbrook Terrace, Illinois, United States

CNS Research Institute

🇺🇸

Clementon, New Jersey, United States

Croft Group Research Center

🇺🇸

San Antonio, Texas, United States

Claghorn-Lesem Research Clinic

🇺🇸

Bellaire, Texas, United States

Northwest Clinical Research Center

🇺🇸

Bellevue, Washington, United States

Summit Research Network (Seattle), LLC

🇺🇸

Seattle, Washington, United States

© Copyright 2025. All Rights Reserved by MedPath