Effects of Gastric Bypass Surgery on Bile Acid Homeostasis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Percentage of orally ingested exogenic bile acid that is retained in the body after 7 days
研究概览
简要总结
The purpose of this study is to determine whether the bile acid circulation is changed after gastric bypass surgery. Further, to account for how the changed anatomy of the gut influences how the bile acid and food is mixed in the gut and how this is associated with the changes in gut hormone release after the surgery.
Our hypothesis is that bile acid reabsorption from the gut is increased as animal models suggest so and bile acid blood concentration increases after surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 25 and 65 years
- •For patients: uncomplicated Roux-en-Y Gastric Bypass surgery more than 12 months before study initiation
- •For controls: Age, BMI and gender matched with patient group
排除标准
- •Previous removal of gall bladder or other abdominal surgeries except appendectomy (and gastric bypass surgery for patient group)
- •Known liver disease or thyroid disease requiring antithyroid medication
- •Chronic gastrointestinal symptoms
- •Any chronic disease interfering with, or susceptive of interfering with appetite or gastrointestinal function
- •Any medication interfering with, or susceptive of interfering with appetite or gastrointestinal function
- •Smoking within the last month
- •Alcohol consumption above 168 grams per week
- •Currently pregnant or breast-feeding
- •Anaemia with haemoglobin <6,5 mmol/L (<117 mg/dl)
- •Loss or gain of more than 3 kg within the last 3 months
结局指标
主要结局
Percentage of orally ingested exogenic bile acid that is retained in the body after 7 days
时间窗: Patients: >12 months after Gastric Bypass Surgery
Differences in time from food intake to mix of food in the gut with bile acid between patients and controls
时间窗: Patients: >12 months after Gastric Bypass Surgery
次要结局
未报告次要终点
研究者
Carsten Dirksen
MD, PhD
Hvidovre University Hospital