NCT02902016已完成不适用
Modulation of Lactase Expression by a New Synthetic PPARgamma Ligand in Ex-vivo Cultures of Duodenal Biopsies
University Hospital, Lille1 个研究点 分布在 1 个国家目标入组 22 人开始时间: 2015年7月16日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- LCT mRNA expression measured by quantitative RT-PCR in duodenal biopsies stimulated ex-vivo with a new PPARgamma agonist (GED, 1mM)
研究概览
简要总结
This study is designed to assess the effect of a new PPARgamma modulator on the expression and activity of the lactase enzyme in human intestinal epithelial cells. Based on their previous experimental results, the investigators hypothesized that modulating intestinal PPARgamma activity is a new pharmacological mechanism allowing the control of lactase expression and activity in the gut
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects undergoing gastroduodenal endoscopy for digestive cancer screening
- •Subjects undergoing gastroduodenal endoscopy for ulcerative gastroduodenal diseases
- •Subjects undergoing gastroduodenal endoscopy for epigastric pains
- •Subjects undergoing gastroduodenal endoscopy for gastroesophageal reflux diseases
排除标准
- •Subjects with macroscopic duodenal lesions detected at endoscopy
- •Subjects suffering from coeliac disease
- •Subjects suffering from atrophic gastritis
- •Subjects who use anticoagulant
- •Pregnancy or breast feeding
研究组 & 干预措施
Lactase expression induction by GED
Experimental
干预措施: GED (Drug)
结局指标
主要结局
LCT mRNA expression measured by quantitative RT-PCR in duodenal biopsies stimulated ex-vivo with a new PPARgamma agonist (GED, 1mM)
时间窗: 2 years
次要结局
- LCT mRNA expression measured by quantitative RT-PCR in primary intestinal epithelial cells (isolated from duodenal biopsies) stimulated with a new PPARgamma agonist (GED, 1mM)(2 years)
研究者
研究点 (1)
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