The Effect of Dexmedetomidine on Emergence Agitation in Children Undergoing a Surgery Under Desflurane Anesthesia
Overview
- Phase
- Phase 4
- Intervention
- Dexmedetomidine
- Conditions
- Psychomotor Agitation
- Sponsor
- Seoul National University Hospital
- Enrollment
- 116
- Locations
- 1
- Primary Endpoint
- Agitation score
- Last Updated
- 14 years ago
Overview
Brief Summary
After genernal anesthesia using sevoflurane or desflurane, the investigators can observe many cases of agiation (over 80%) and despite of no report of long-term complication, agitation is a big issue in PACU for doctors and nurses. The investigators use dexmedetomidine for prevention of agiation of preschool aged children. The investigators expect single injection of dexmedetomidine lead to decrease postoperative agitation and pain without any complication like oculocardiac reflex requiring atopine for treatment.
Detailed Description
There are four groups accoding to dosage of dexmedetomidine. Dexmedetomidine 0.25 microg.kg(-1),(group D0.25), dexmedetomidine 0.5 microg.kg(-1),(Group D0.5), dexmedetomidine 1 microg.kg(-1) (Group D 1) and normal saline(group P) is administered ivs. for 10mins when we are inducing each patient.
Investigators
Ah-Young Oh
Assistant Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Physical status classification of American Society of Anesthesiologist 1-2,
- •Healthy, normal
- •2-6 years old
- •Elective operation
Exclusion Criteria
- •Lack of consent
- •Known adverse effects to dexmedetomidine, mental retardation
- •Developmental delay, or neurological or psychiatric illness that may associate with agitation (cerebral palsy, seizure, etc)
- •No cardiac disease
Arms & Interventions
Dexmedetomidine0.25
dexmedetomidine 0.25 microg.kg(-1),(Group D0.25) ivs. for 10min.
Intervention: Dexmedetomidine
Dexmedetomidine0.5
dexmedetomidine 0.5 microg.kg(-1),(group D0.5) ivs. for 10min.
Intervention: Dexmedetomidine
Dexmedetomidine1.0
dexmedetomidine 1 microg.kg(-1) ivs. for 10min.
Intervention: Dexmedetomidine
NormalSaline
Normal saline 10ml ivs. for 10min.
Intervention: 0.9% Normal Saline
Outcomes
Primary Outcomes
Agitation score
Time Frame: 30 mins after operation
Secondary Outcomes
- Oculomotor reflex(Intraoperative)