Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Elderly
- Sponsor
- Duke University
- Enrollment
- 108
- Locations
- 2
- Primary Endpoint
- Change In Exercise Capacity
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The aim of this study is to devise a sufficiently high intensity training program that provided an optimal stimulus to remove the peripheral factors known to reduce functional capacity, and can be cardiovascular and orthopedically well tolerated by the elderly. Findings from study laboratories have suggested that a regional specific training stimulus (RSTS) results in rapid improvements in both vascular and muscular function. RSTS is a novel combination of resistance training and aerobic training applied simultaneously, and in a serial manner, to specific regions of the body. It involves high-intensity and frequency muscle contractions, generating a targeted exercise stimulus, without producing excessive cardiovascular or orthopedic stress. The hypothesis is that initiating training with RSTS at multiple, strategically selected peripheral sites, in a serial manner will elicit local vascular and muscular changes, thereby preparing individuals at elevated risk of losing independence, to respond and progress more favorably to whole-body exercise.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\>70 yrs of age
- •Sedentary (exercising \<1 day/wk)
- •Non-smokers
- •Able to ambulate without use of an assistive device
- •Able to walk between 200-450m on a 6-minute walk test
Exclusion Criteria
- •Oxygen dependent
- •Recent medications changes (within 3 months)
- •Current Smokers
- •Fixed-rate pacemakers
- •Uncontrolled hypertension or Type II diabetes
- •Positive ECG changes or angina during CPX testing
- •Unable to complete a maximal CPX to volitional fatigue
- •AHA Class D, or NYHA Class III or IV heart failure
Outcomes
Primary Outcomes
Change In Exercise Capacity
Time Frame: Baseline, 4 weeks, and 12 weeks
Exercise capacity was assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of peak oxygen consumption and peak walking time.
Change in Maximal Strength
Time Frame: Baseline, 4 weeks, and 12 weeks
Skeletal muscle strength was assessed using a one repetition maximum (1RM) measurement obtained for the seated row, chest press, leg press and handgrip.
Secondary Outcomes
- Change in Skeletal Muscle Physiology(Baseline, 4 weeks, and 12 weeks)
- Change in Functional Ability(Baseline, 4 weeks and 12 Weeks)
- Change In Vascular Function(Baseline, 4 weeks, and 12 weeks)