Comparison of efficacy of high dose magnesium sulfate infusion versus standard dose magnesium infusion in moderate to severe asthma exacerbation in childre

Phase 2

• Conditions: - Efficacy compare normal dose and high dose in MgSO4 treatment - High dose magnesium sulfate is save for asthma exacerbation treatment; moderate to aevere asthma; magnesium sulfate in asthma; high dose magnesium sulfate

• Registration Number: TCTR20191118001
• Lead Sponsor: Faculty of medicine, Thammasart university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-11-18
• Study Completion: 2020-02-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

- Age 2-15 years
- Moderate to severe asthma exacerbation (Thammasat asthma score ≥ 5, SpO2 < 95%)
- Non respond to SABAs or anticholinergic 3 doses with systemic corticosteroid

Exclusion Criteria

- BT > 38.5 C
- Hypotension < P25
- Renal, pulmonary, cardiology disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical and therapeutic responder 1-6 hr after after treatment Clinical asthma score

Secondary Outcome Measures

Name	Time	Method
Adverse events 1-6 hr after after treatment Serum magnesium sulfate and blood pressure and clinical apnea