Open Randomized Study of Patients With Chronic Heart Failure and Cheyne Stokes Respiration Pattern, Treated With ASV. (Adaptive Servo Ventilator).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Ejection fraction (measured with echocardiography) and inflammatory markers
研究概览
简要总结
An investigation where patients with chronic heart failure and cheyne stokes respiration, treated with adapitve servo ventilator, will improve their cardiac function and quality of life.
详细描述
Chronic heart failure (HF) is one of the most important public health problems in cardiovascular medicine.
Several patients with chronic heart failure also has Cheyne Stokes respiration pattern. Earlier studies have shown that this respiration pattern improves with Adaptive servo ventilator. We wish to investigate wether this leads to improved cardiac function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ejection fraction <40%
- •NYHA class III-IV
- •Optimized therapy with drugs
- •Cheyne stokes respiration pattern > 25% while sleeping
- •Age < 85 years
- •clinical stability the last month before inclusion.
排除标准
- •CABG less then 6 months ago
- •PCI treatment less then 3 months ago
- •Unstable angina pectoris
- •Acute coronary syndrome less then 3 months ago
- •Stroke less then 6 weeks ago
- •Thoracal myopathy
- •Advanced COPD
研究组 & 干预措施
B
Patients without ASV
干预措施: without Autoset CS2 (Other)
A
The patients use ASV
干预措施: without Autoset CS2 (Other)
A
The patients use ASV
干预措施: ASV (Device)
结局指标
主要结局
Ejection fraction (measured with echocardiography) and inflammatory markers
时间窗: 3 months
次要结局
- 6 minutes walking test Quality of life Changes in cathecolamines Altered frequency of arrythmias(3 months)