Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes
研究概览
简要总结
Randomised training intervention.
Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell
Sarcopenia
Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible.
Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •no fever at the beginning and during the study
- •between 60 years and 75 years
- •non smokers
- •no known cardiovascular and orthopaedic problems
- •no cardiac pacemaker
- •fulfilling the health criteria
排除标准
- •fever or cold at the beginning or during the study
- •non MRI compatible metal implants
- •under 60 years or over 75 years
- •cardiovascular or orthopaedic problems
- •cardiac pacemaker
- •not fulfilling the health criteria
研究组 & 干预措施
Endurance and Resistance Training
Endurance and resistance exercise
干预措施: Training (Procedure)
Resistance Training
resistance exercise (12wk)
干预措施: Training (Procedure)
Resistance and resistance Training
resistance exercise (24 wk)
干预措施: Training (Procedure)
结局指标
主要结局
Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes
时间窗: participants will be followed for the duration of training period, an expected average of 7 months
Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain \[um\^2\], myonuclear number \[%\] in response to consecutive training regimes
次要结局
未报告次要终点