Association Between Handgrip Strength and Small Airway Disease in Patients with Stable Chronic Obstructive Pulmonary Disease

Completed

• Conditions: COPD
• Interventions: Diagnostic Test: Handgrip strength

• Registration Number: NCT06223139
• Lead Sponsor: Thammasat University

Brief Summary

The goal of this observational study is to investigate the correlation between handgrip strength and small airway disease among patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is:

• Is handgrip strength correlated with small airway disease in COPD patients? Participants will perform handgrip strength test and impulse oscillometry (IOS).

Detailed Description

This is a cross-sectional study in COPD patients. COPD patients aged 40 years or older were included. Handgrip strength test and impulse oscillometry will be tested in each patient. Handgrip strength will be measured using a hand dynamometer. Small airway disease will be assessed using IOS.

Study Timeline

• Study Start: 2023-03-01
• Study First Submitted: 2024-01-12
• Study First Submitted QC: 2024-01-22
• Study First Posted: 2024-01-25
• Primary Completion: 2024-01-31
• Study Completion: 2024-05-31
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-16
• Last Update Posted: 2025-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• COPD patients aged 40 years or older
• Confirmed diagnosis by spirometry (post-bronchodilator FEV1/FVC <0.7)
• Smoking history 10 pack-years or more

Exclusion Criteria

• COPD exacerbation within 3 months
• Inability to perform handgrip strength test or impulse oscillometry

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COPD	Handgrip strength	COPD patients aged 40 years or older with a post-bronchodilator ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) \<0.7.

Primary Outcome Measures

Name	Time	Method
Correlation between handgrip strength and small airway disease in COPD patients	At day 1 of the study	This correlation will be reported as correlation coefficient (R).

Secondary Outcome Measures

Name	Time	Method
The best cutoff value of handgrip strength for predicting small airway disease in COPD patients	At day1 of the study	The best cutoff value will be determined by the area under the Receiver Operator Characteristic curve (ROC).

Trial Locations

Locations (1)

Thammasat University Faculty of Medicine; 🇹🇭 Pathumthani, Thailand