Correlation Between Handgrip Strength and Air Trapping in Patients With Stable Chronic Obstructive Pulmonary Disease

Recruiting

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Diagnostic Test: Handgrip strength

• Registration Number: NCT06220851
• Lead Sponsor: Thammasat University

Brief Summary

The goal of this observational study is to investigate the relationship between handgrip strength and air trapping in patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is:

• Is handgrip strength correlated with air trapping in COPD patients? Participants will perform handgrip strength test and lung volume measurement.

Detailed Description

This is a cross-sectional study in COPD patients. COPD patients aged 40 years or older were included. Handgrip strength test and lung volume measurement will be tested in each patient. Handgrip strength will be measured using a hand dynamometer. Lung volume will be assessed using a body plethysmograph.

Study Timeline

• Study First Submitted: 2024-01-12
• Study First Submitted QC: 2024-01-23
• Study First Posted: 2024-01-24
• Study Start: 2024-02-20
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-28
• Last Update Posted: 2024-04-01
• Primary Completion: 2024-04-30
• Study Completion: 2024-05-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• Age 40 years or older
• Postbronchodilator FEV1/FVC <0.7
• >10 pack-year smoking history

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Exclusion Criteria

• COPD exacerbation within 3 months
• Inability to perform handgrip strength test or lung volume measurement

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COPD	Handgrip strength	COPD patients aged 40 years or older with a postbronchodilator ratio of forced expiratory volume at one second (FEV1) to forced vital capacity (FVC) \<0.7.

Primary Outcome Measures

Name	Time	Method
Correlation between handgrip strength and air trapping in COPD patients	At day 1 of the study	This correlation will be reported as correlation coefficient (R).

Secondary Outcome Measures

Name	Time	Method
The best cutoff value of handgrip strength for predicting air trapping in COPD patients	At day 1 of the study	The best cutoff value will be determined by the area under the Receiver Operator Characteristic curve (ROC).

Trial Locations

Locations (1)

Thammasat University Faculty of Medicine; 🇹🇭 Pathumthani, Thailand