NCT00854178已完成4 期
Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
UPECLIN HC FM Botucatu Unesp1 个研究点 分布在 1 个国家目标入组 26 人开始时间: 2008年3月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Evaluation of genotoxicity, gene expression, apoptosis and cytokines profile
研究概览
简要总结
The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.
详细描述
It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients in good health American Society of Anesthesia status physical I
- •elective minor surgery
- •general anesthesia
排除标准
- •alcoholics
- •previous medication or radiation
研究组 & 干预措施
2
Experimental
干预措施: Comparison of two anesthetic drugs (Drug)
结局指标
主要结局
Evaluation of genotoxicity, gene expression, apoptosis and cytokines profile
时间窗: within 1 day after surgery
次要结局
未报告次要终点
研究者
研究点 (1)
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