Cardiovascular Patients With no Standard Modifiable Risk Factors

Completed

• Conditions: Cardiovascular Risk Factors

• Registration Number: NCT06199869
• Lead Sponsor: Jordan Collaborating Cardiology Group

Brief Summary

A growing number of patients develop atherosclerotic cardiovascular disease (ASCVD) despite the absence of standard modifiable risk factors (SMuRF-less). There is scarcity of studies that address this issue in the Middle Eastern population.

Detailed Description

Atherosclerotic coronary artery disease (ASCAD) claims millions of lives annually on a global level and is the leading cause of death in the Middle East. There are four standard modifiable cardiovascular risk factors (SMuRFs): hypertension, type 2 diabetes mellitus, dyslipidemia, and smoking. These are very common in the Middle East and are crucial to be screened for and addressed in an affective manner.

However, an increasing proportion of patients with ASCVD have none of these individual factors (SMuRF-less). Globally, this proportion comprises 11.6% of individuals with stable coronary disease and heart attack. No prior study has addressed the issue of the prevalence of SMuRF-less patients among the whole population of individuals with ASCVD in the Middle East.

Study Timeline

• Study First Submitted: 2023-12-25
• Study First Submitted QC: 2024-01-09
• Study First Posted: 2024-01-10
• Study Start: 2024-01-22
• Primary Completion: 2025-01-01
• Study Completion: 2025-01-31
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-23
• Last Update Posted: 2025-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5540

Inclusion Criteria

• A diagnosis of atherosclerotic cardiovascular disease (ASCVD).
• Ability to fill the clinical form that evaluates the presence or absence of cardiovascular risk factors including the 4 SMuRFs.

Exclusion Criteria

• Atherosclerotic cardiovascular disease diagnosed before the age of 18 years.
• Inability to give detailed history of prespecified risk factors.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of patients who do not any of the four SMuRFs	Up to 4 weeks after study enrollment	Group of patients with definite ASCVD who do not have hypertension, diabetes, dyslipidemia or smoking.

Trial Locations

Locations (2)

Istishari Hospital; 🇯🇴 Amman, Jordan

Yarmouk University School of Medicine; 🇯🇴 Irbid, Jordan