Emdogain and nonsurgical therapy of periodontitis

Not Applicable

• Conditions: K05.3; Chronic periodontitis

• Registration Number: DRKS00022865
• Lead Sponsor: niversitätsklinikum Leipzig AöR

Brief Summary

For the primary outcome “change of mean PPD after 6 months,” a significant additional benefit of 0.79 ± 1.3 mm (p < .0001) could be observed for the test group. At 12 months, this difference could be maintained (0.85 ± 1.1 mm; p < .0001). The frequency of pocket closure in the test group was 69% at 6 and 80% at 12 months and significantly higher than in the control group with 34% and 42%, respectively (p < .01). The results of the present feasibility study indicate a benefit of adjunctive EMD during non-surgical retreatment (step 3 of periodontal therapy) of residual deep pockets.

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-10-12
• Study Start: 2020-08-13
• Results First Posted: 2021-12-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• no systemic diseases with influence on the immune system/response
• no antibiotic within the last three months

Exclusion Criteria

• age = 18 years
• disabled patients
• gravidity
• lactation
• diseases or medication with influence on wound healing
• infectious diseases (hepatitis, HIV)
• smoking (> 10 cigarettes per day)
• drug and alcohol abuse
• ulcerative/necrotising periodontitis

Study & Design

• Study Type: interventional
• Study Design: Not specified