Evaluation of the effect of non-surgical periodontal treatment on disease activity in patients with ankylosing spondylitis

Not Applicable

Recruiting

Conditions: Periodontal disease - ankylosing spondylitis.
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Z40-Z54

Registration Number: IRCT20161106030744N3

Lead Sponsor: Gorgan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 96

Inclusion Criteria

18 years of age or older
Confirmed diagnosis of active AS by a rheumatologist
Moderate to severe generalized chronic periodontitis
Patients who have at least 20 teeth

Exclusion Criteria

Antibiotic use in a period of 3 months before the study
Received non-surgical periodontal treatment in the last 6 months
smoking
Severe liver or kidney failure
Uncontrolled diabetes
Heart disease
History of radiation therapy or chemotherapy
Taking drugs with a possible effect on the periodontium (such as cyclosporine, phenytoin, calcium channel blockers)
Severe dry mouth
Pregnancy and breastfeeding
Patients who do not return to measure the investigated variables in the sixth and twelfth weeks

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bath Ankylosing Spondylitis Disease Activity(BASDAI). Timepoint: 0_ 12 weeks after the intervention. Method of measurement: The BASDAI consists of a 0-10 scale (0 being no problem and 10 being the worst problem) that is used to answer 6 questions related to the 5 main AS symptoms.

Secondary Outcome Measures

Name	Time	Method
Periodontal indices (PI, GI, PPD, GBI, CAL). Timepoint: 0_ 6 weeks after the intervention_ 12 weeks after the intervention. Method of measurement: CAL: The distance from Cej to the apical depth of the probe is in millimeters. GBI: whether probing causes bleeding (+) or not (-) is assessed. PPD: the distance from the free margin of the gingiva to the bottom of the sulcus depth in millimeters. GI: ??evaluation of the intensity and amount of gingival inflammation with BOP of the tooth. PI: It is based on the registration of soft debris and mineral deposits on the following teeth: upper right first molar, upper right lateral, upper left first premolar, lower left first molar, lower left lateral and lower right first premolar.