Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years

• Conditions: Osteoporosis; Anorexia Nervosa
• Interventions: Device: DEXA

• Registration Number: NCT02891356
• Lead Sponsor: University Hospital, Lille

Brief Summary

The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)

Detailed Description

Not available

Study Timeline

• Study Start: 2013-07
• Study First Submitted: 2016-09-01
• Study First Submitted QC: 2016-09-01
• Study First Posted: 2016-09-07
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-24
• Last Update Posted: 2020-08-25
• Primary Completion: 2022-07
• Study Completion: 2022-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 180

Inclusion Criteria

• anorexia patient defined by DSM IV diagnostic criteria

Exclusion Criteria

• patient with other psychiatric disease
• patient with other a metabolic bone disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Anorexia patient	DEXA	Dual Energy X-ray Absorptiometry (DEXA)

Primary Outcome Measures

Name	Time	Method
Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA)	4 years	measured the evolution of the bone mineral density in 180 anorexia nervosa patients and the relationship with this change and adipokine

Secondary Outcome Measures

Name	Time	Method
Adiponectin plasma concentration by ELISA	at 2,4 and 6 years	measurement of circulating biological factors predicative of changes in BMD
Incidence of osteoporotic fractures	at 2,4 and 6 years
Interleukin-7 plasma concentration by ELISA	at 2,4 and 6 years	measurement of circulating biological factors predicative of changes in BMD

Trial Locations

Locations (1)

Hôpital Roger Salengro, CHRU de Lille; 🇫🇷 Lille, France