Semaphorins 3A and 4D Levels in Heart Failure Patients: Pathogenesis and Clinical Correlation
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 主要终点
- Semaphrone 3A and 4D levels
研究概览
简要总结
This study hypothesis is that Semaphorins 3A and 4D levels are overexpressed in patients with heart failure. Study protocol:
Hospitallized patients with new onset or previously diagnosed heart failure will be recruited to the study. Control group will include healthy people with no medical records or chronic treatment at the same age range. After signing an informed constent form, full medical history and blood samples will be collected. A second blood sample will be collected 8 weeks later, assuming the patient was discharged and not hospitalized since than. The blood samples will be analyzed by Bnai Zion Medical Center Immunology labs for the above semaphorins levels in the heart failure group and control group. Statistical analysis will then commence for possible correlatoion with different clinical parameters.
详细描述
In few previous published studies, Semaphorins 3A levels are overexpressed in patients with heart failure. The aim of our study is the compare semaphorin 3A and 4D in patients with acute decompansated heart failure with healthy donors. Second aim is to compare semaphorin level in the same patients in time of hospitalization and few weeks later when the heart failure presumingly controled. Statistical analysis will then commense for possible correlatoion with different clinical parameters like NYHA (new york heart association) status of the patient, lenghts of hospitalization and BNP (brain natriuretic peptide) levels at time of admition.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with new onset or previously diagnosed heart failure.
- •Heart failure diagnosis can be based on clinical judgment, echocardiography or elevated BNP levels
排除标准
- •Patients with acute myocardial infarction diagnosed clinicly and labratory
结局指标
主要结局
Semaphrone 3A and 4D levels
时间窗: one year
次要结局
- BNP level(one year)