NCT01153360已完成不适用
Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- compare the serum T3 concentrations and the number of patients with serum T3 concentrations below the normal range between the groups
研究概览
简要总结
This study is planned to medicate oral T3(Liothyronine)to the patients who are planned to have OPCAB(off- pump coronary bypass graft surgery. The aim of this study was to assess the effects of oral triiodothyronine (T3) therapy on postoperative thyroid hormone concentrations, hemodynamic variables and outcomes in patients undergoing OPCAB in a randomized, controlled trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who are undergoing Off-pump coronary artery bypass graft
排除标准
- •No normal sinus rhythm,
- •History of thyroid disease
- •Abnormal thyroid hormone
- •Renal dysfunction
- •Hepatic dysfunction
- •LVEF <30%
- •Recent MI
- •Active infection 1~15
研究组 & 干预措施
T3
Experimental
triiodothyronine
干预措施: liothyronine sodium (Drug)
cyanocobalamin
Active Comparator
vitamin B12
干预措施: placebo (Drug)
结局指标
主要结局
compare the serum T3 concentrations and the number of patients with serum T3 concentrations below the normal range between the groups
时间窗: until 36 hours after surgery
次要结局
- difference of hemodynamic performance and myocardial injury(during surgery and 36 hr after surgery)
研究者
Yong-Sun Choi
assistant professor
Yonsei University
研究点 (1)
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