MYOcardial ischemia detection by circulating bioMARKERs: * the MYOMARKER-study*
Completed
- Conditions
- angina (pectoris)ischemic coronary artery disease10011082
- Registration Number
- NL-OMON40975
- Lead Sponsor
- Meander Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 1265
Inclusion Criteria
Patients (age >18yr), who are being evaluated in the Meander Medical Center cardiology outpatient clinic with symptoms suggestive for ischemic coronary artery disease, and who will undergo radionuclide myocardial perfusion imaging (rMPI) as indicated by their own cardiologist.
Exclusion Criteria
- Age <18 years at time of inclusion
- Patients from whom no informed consent is obtained
- Incapacitated adults; language barriers or other obstacles for full
understanding of the study objectives.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Parameter; Extracellular vesicle protein- and miRNA-concentration, and gene<br /><br>expression profiles in circulating cells.<br /><br>Endpoint: Objectified ischemic coronary artery disease, determined by<br /><br>radionuclide myocardial perfusion imaging (Rubidium-82).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Follow-up: all-cause mortality, cardiovascular death, non-fatal MI, coronary<br /><br>revascularisation, stroke, and peripheral vascular interventions.</p><br>