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临床试验/NCT04100369
NCT04100369Unknown不适用

Admission Blood Glucose as a Predictor of Morbidity and Mortality in Polytraumatized Patients

Assiut University0 个研究点目标入组 100 人开始时间: 2020年1月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
主要终点
Admission blood glucose as a predictor of morbidity and mortality in polytraumatized patients

研究概览

简要总结

In polytrraumatized patients, Does hyperglycaemia on admission increase the risk of morbidity and mortality compared to polytraumatised patients with normal blood glucose level ?

详细描述

Trauma is still the leading cause of death in young adults and a major cause of morbidity and mortality at all ages.(1,2). Polytrauma is defined as injury to several physical regions or organ systems, where at least one injury or the combination of several injuries are life threatening with the severity of injury being equal or >16 on the scale of the Injury Severity Score (ISS). Prediction of mortality in trauma patients is an important part of trauma care (3). The trauma and injury severity score (TRISS) and Acute Physiology and Chronic Health Evaluation IV (APACHE IV) are used commonly to predict injury severity and risk of mortality. Although it is regarded as the international standard in trauma scoring, it has complex calculating and incorporates the Glasgow Coma Scale (GCS) for neurological evaluation (4). Regardless of the accuracy of trauma scores, is based on an anatomical description of every injury and cannot be assigned to the patients until a full diagnostic procedure has been performed(5) . Many studies have revealed alteration in glucose metabolism in trauma and proportional relation of its high level to the degree of injury (6). hyperglycaemia is associated with similar complications as uncontrolled diabetes, including an increased mortality, an increased number of infectious complications, and poor wound healing. The presence of elevated blood glucose also impedes normal host defences against infection and impairs the normal inflammatory response (7.8).

  • Therefore, this study will be conducted to compare between alterations in easy and rapid predictors as glucose level, base deficit and lactate and difficult and slow predictors as TRISS and APACHE IV. So, it could be considered an early and easy rapid predictor of outcome .

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • • Age >= 18 years
  • Polytrauma ISS >= 18
  • Recent polytrauma patients who are directly transferred by the ambulance from the scene of accident to assiut university hospital and did not receive resuscitative measurements in another hospital

排除标准

  • known co-morbidities affecting blood glucose level like :
  • Pregnant women
  • Diabetic patients

结局指标

主要结局

Admission blood glucose as a predictor of morbidity and mortality in polytraumatized patients

时间窗: baseline

to investigate the admission blood glucose level as a predictor of morbidity and mortality in poly traumatized patients

次要结局

  • Admission blood glucose as a predictor of morbidity and mortality in polytraumatized patients(baseline)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

tamer refaat hanna armanious

Assistant Lecturer

Assiut University

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