Oxytocin and the placebo effect.

Completed

• Conditions: Placebo effect in healthy subjects

• Registration Number: NL-OMON27820
• Lead Sponsor: eiden University

Brief Summary

n/a

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 108

Inclusion Criteria

1.Healthy female volunteers between 18 and 35 years old;

2.Good understanding of written and spoken Dutch.

Exclusion Criteria

1.Current psychiatric (DSM-IV) conditions;

2.All conditions that might interfere with the participant's safety and/or the study protocol: e.g., Raynaud’s phenomenon, severe neurological or neurosurgical conditions;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The main study outcome is the difference between the oxytocin with positive suggestions group (group 1) and the placebo with positive suggestions group (group 3) on self-reported pain ratings and on self-reported itch ratings. Self-reported pain will be assessed in response to the CPT after the intervention controlled for the baseline CPT self-reported pain ratings. Self-reported itch ratings will be assessed in response to HI.

Secondary Outcome Measures

Name	Time	Method
•The difference between the oxytocin without positive suggestions group (group 2) and the placebo without positive suggestions group (group 4) on self-reported pain and itch ratings in response to the CPT and histamine test to investigate the effects of oxytocin on pain and itch sensitivity<br /><br>•The difference between the placebo with positive suggestions group (group 3) and placebo without positive suggestions group (4) on self-reported pain and itch ratings in response to the CPT and histamine test to investigate the effects of verbal suggestions on pain and itch sensitivity<br /><br>