ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for PatientsWith Acute Ischemic Stroke Due to Tandem Lesio

Phase 1

• Conditions: Acute Ischemic Stroke; MedDRA version: 22.1Level: LLTClassification code: 10055221Term: Ischemic stroke Class: 10029205; MedDRA version: 20.0Level: SOCClassification code: 10047065Term: Vascular disorders Class: 12; MedDRA version: 20.0Level: HLGTClassification code: 10003216Term: Arteriosclerosis stenosis vascular insufficiency and necrosis Class: 10047065; MedDRA version: 22.1Level: PTClassification code: 10061256Term: Ischaemic stroke Class: 100000004852; MedDRA version: 20.0Level: HLTClassification code: 10008192Term: Cerebrovascular and spinal necrosis and vascular insufficiency Class: 10047065; Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]

• Registration Number: CTIS2023-508454-26-00
• Lead Sponsor: Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-02-27
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

Patients with acute ischemic stroke of the anterior territory secondary to a tandem lesion, with an indication for thrombectomy treatment according to the current recommendations of the Clinical Practice Guidelines, and the need for cervical stent placement., The intracranial occlusion locations that may be included are: carotid T, M1 and M2 segments of the middle cerebral artery, segment A1 of the anterior cerebral artery; and in the case that the posterior cerebral artery has fetal origin and is the site of intracranial occlusion., ASPECTS (Alberta Stroke Program Early computerized Tomography Score) =6., Greater than or equal to 18 years of age., Signed informed consent.

Exclusion Criteria

Patients under 18 years of age., Pregnant., Patients with intracranial occlusive arteriosclerotic disease or extra or intracranial dissection., Documented allergy to acetylsalicylic acid or Tirofiban., Personal history of platelet penia (Platelets <100,000), Concomitant anticoagulant treatment (with presence of INR (International Normalized Ratio) > 1.7 in case of anti-vitamin K treatment or taking direct oral anticoagulant <48 hours ago), Medical history of the patient that carries a high risk of bleeding according to the investigator's criteria., Peptic ulcer active in the last 3 months., Patients with ASPECTS <6., Bilateral strokes or those produced by simultaneous occlusion of an artery in the anterior and posterior territory., Patients whose carotid stenosis is due to a re-stenosis or reocclusion of a pre-existing cervical stent., Candidate patients for carotid puncture., Previous treatment with double antiplatelet therapy for another cause prior to inclusion., Severe comorbidity and / or reduced life expectancy., Modified Rankin scale (mRS)> 2., Severe allergy to contrast medium.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified