NCT00743964已完成2 期
A Randomized Phase II Study of Combination Chemotherapy With Epirubicin , Cisplatin and Capecitabine (ECX) or Cisplatin and Capecitabine (CX) in Advanced Gastric Cancer
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 91
- 试验地点
- 1
- 主要终点
- Failure-free survival
研究概览
简要总结
Recently, 3-drug (ECX) and 2-drug (CX) combination chemotherapy involving capecitabine showed promising results in randomized clinical trials for advanced gastric cancer (AGC). The objective of the study is to evaluate the safety and activity of ECX and CX combination chemotherapy given as first-line therapy for AGC.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 75 years or less
- •Adenocarcinoma of stomach
- •Advanced, metastatic, or recurrent
- •No prio chemotherapy for advanced disease
- •Adequate performance status
- •Adequate major organ functions
排除标准
- •Severe comorbid illness or active infections
- •Pregnancy or lactating women
- •GI obstruction or malabsorption syndrome
研究组 & 干预措施
ECX
Experimental
Epirubicin, cisplatin and capecitabine combination chemotherapy will be administered.
干预措施: Epirubicin (Drug)
ECX
Experimental
Epirubicin, cisplatin and capecitabine combination chemotherapy will be administered.
干预措施: Cisplatin, capecitabine (Drug)
CX
Active Comparator
Cisplatin and capecitabine combination chemotherapy will be administered.
干预措施: Cisplatin, capecitabine (Drug)
结局指标
主要结局
Failure-free survival
时间窗: six months
次要结局
- progression-free survival(six months)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
2 期
Safety and Efficacy Study to Compare Capecitabine + Bevacizumab Versus Capecitabine, Concomitantly With Radiotherapy as Neoadjuvant Treatment for Patients With Localized and Resectable Rectal CancerRectal CancerNCT01043484Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)90
已完成
2 期
Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid LeukemiaAdult Acute Megakaryoblastic Leukemia (M7)Adult Acute Minimally Differentiated Myeloid Leukemia (M0)Adult Acute Monoblastic Leukemia (M5a)Adult Acute Monocytic Leukemia (M5b)Adult Acute Myeloblastic Leukemia With Maturation (M2)Adult Acute Myeloblastic Leukemia Without Maturation (M1)Adult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Inv(16)(p13;q22)Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)Adult Acute Myelomonocytic Leukemia (M4)Adult Erythroleukemia (M6a)Adult Pure Erythroid Leukemia (M6b)Recurrent Adult Acute Myeloid LeukemiaNCT00634244National Cancer Institute (NCI)92
已完成
2 期
Study of Capecitabine With Irinotecan and Oxaliplatin (Eloxatin) in Advanced Colorectal CancerColorectal CancerNCT00215982H. Lee Moffitt Cancer Center and Research Institute24
终止
2 期
A Phase II Trial of Gemcitabine, Capecitabine, and Bevacizumab in Metastatic Renal Cell CarcinomaCarcinoma, Renal CellNCT00523640University of Chicago30
已完成
2 期
Study of Chemotherapy Combination With Autologous Cytokine-Induced Killer Cell Immunotherapy to Treat Lung CancerNon-small Cell Lung CancerSquamous Cell CarcinomaNCT01631357Tianjin Medical University Cancer Institute and Hospital96