IRCT2017082013442N17Recruiting未知
The comparison of effects of intra - articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and Ozone Gas on pain, stiffness, and function of patients with knee osteoarthritis
Vice chancellor for research, Shahid Beheshti University of Medical Sciences0 sites120 target enrollmentStarted: TBDLast updated:
Trial Snapshot
- Phase
- 未知
- Status
- Recruiting
- Sponsor
- Enrollment
- 120
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 50 years to 70 years (—)
- Sex
- All
Inclusion Criteria
- •Patients with knee osteoarthritis according to the American College of Rheumatology criteria aged between 50-70 years and with symptoms that have been diagnosed for more than 3 months and radiologic evidence of articular damage (grade 1-4 of Kellgren-Lawrence scale)
- •Exclusion criteria: 1- systemic diseases such as diabetes mellitus, Immunodeficiency and collagen vascular disorders 2- history or presence of cancer or malignant disorders 3- any infection and active wound of the knee 4-presence of autoimmune diseases and platelet disorders 5- use of NSAIDs 2 days before injection 6- treatment with anticoagulant and anti-platelet medications 10 days before injection 7-history of knee articular injections of corticosteroids 3 weeks or use of systemic corticosteroids 2 weeks before injections 8-hemoglobin measures of less than 12 g/dl and platelet counts of less than 150,000 per micro liter 9- recent history of severe trauma to the knee 10-age less than 40 or over 75 years 11- history of vasovagal shock 12-pregnancy and breastfeeding 13- genu valgum/varum greater than 20 degrees 14-Allergy to chicken or egg protein or hypersensitivity to hyaluronate 15-patients treated with ACE inhibitors. 16-G6PD deficiency
Exclusion Criteria
- Not provided
Investigators
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