The comparison of effects of different intra-articular injections on the symptoms of patients with knee osteoarthritis

Not Applicable

Recruiting

• Conditions: Knee osteoarthritis.; Gonarthrosis [arthrosis of knee]

• Registration Number: IRCT2017082013442N17
• Lead Sponsor: Vice chancellor for research, Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Patients with knee osteoarthritis according to the American College of Rheumatology criteria aged between 50-70 years and with symptoms that have been diagnosed for more than 3 months and radiologic evidence of articular damage (grade 1-4 of Kellgren-Lawrence scale)
Exclusion criteria: 1- systemic diseases such as diabetes mellitus, Immunodeficiency and collagen vascular disorders 2- history or presence of cancer or malignant disorders 3- any infection and active wound of the knee 4-presence of autoimmune diseases and platelet disorders 5- use of NSAIDs 2 days before injection 6- treatment with anticoagulant and anti-platelet medications 10 days before injection 7-history of knee articular injections of corticosteroids 3 weeks or use of systemic corticosteroids 2 weeks before injections 8-hemoglobin measures of less than 12 g/dl and platelet counts of less than 150,000 per micro liter 9- recent history of severe trauma to the knee 10-age less than 40 or over 75 years 11- history of vasovagal shock 12-pregnancy and breastfeeding 13- genu valgum/varum greater than 20 degrees 14-Allergy to chicken or egg protein or hypersensitivity to hyaluronate 15-patients treated with ACE inhibitors. 16-G6PD deficiency

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Knee pain. Timepoint: before intervention,6 months & 12months after intervention. Method of measurement: changes of WOMAC and VAS questionnaires scores.;Joint Stiffness. Timepoint: before intervention,6 months & 12months after intervention. Method of measurement: change of WOMAC questionnaire scores.;Function. Timepoint: before intervention,6 months & 12months after intervention. Method of measurement: change of WOMAC questionnaire scores.