Metabolome analysis of cachexia and its circadian rhythms in patients with advanced pancreatic cancer.
Not Applicable
- Conditions
- advanced pancreatic cancer
- Registration Number
- JPRN-UMIN000002384
- Lead Sponsor
- Medical Oncology, Kobe University Graduate School of Medicine
- Brief Summary
evels of paraxanthine remained markedly lower in the cohort with cachexia at all measurement points. Besides, median IL-6 and TNF levels appeared higher and leptin concentration appeared lower in the cachexia group, albeit without statistical significance.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 21
Inclusion Criteria
Not provided
Exclusion Criteria
1. resectable pancreatic cancer 2. pancreatic neuroendcrine carcinoma 3. chemotherapy within 1 week 4. surgery within 1 month 5. deffinitive radiotherapy within 1 month 6. palliative radiotherapy within 2 weeks 7. uncontroled infection 8. uncontroled diabetic mellitus 9. condition that required corticosteroid
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The metabolites on cachexia by metabolom analysis
- Secondary Outcome Measures
Name Time Method The circadian rhythms of the metabolites on cachexia