Effects of Steroid Therapy on Quality of Life and Adverse Health outcomes in Primary Adrenal Insufficiency
Not Applicable
- Conditions
- Health Condition 1: E271- Primary adrenocortical insufficiency
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Diagnosed cases of primary adrenal insufficiency including classical CAH of age 18 to 65 years being treated with stable dose of glucocorticoid for last 3 months.
Exclusion Criteria
1.Any secondary cause of adrenal insufficiency.
2. Pregnancy.
3.Chronic disease like CKD, CLD and chronic infections
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quality of life using short-form health survey (SF-36) QoL questionnaire in Primary adrenal insufficiencyTimepoint: outcome will be assessed at baseline, 24 weeks & 48 weeks.
- Secondary Outcome Measures
Name Time Method 1.To compare the change in cardiometabolic parame-ters (HOMA2IR, adiponectin, leptin, hs-CRP) and bone turnover markers (sclerostin, P1NP, CTX) in PAI patients on hydrocortisone or prednisolone treatment at baseline, 6 month and 1 year. <br/ ><br> <br/ ><br> <br/ ><br>2.To compare the change in lumbar spine BMD and Trabecular bone score (TBS) over 1 year in PAI patients on hydrocortisone or prednisolone replacement therapy. <br/ ><br>3.To compare the change in body composition parameters, include lean body mass, fat mass, fat per-centage and android to gynecoid ratio using bioimpedance analyzer (BIA) and dual energy x-ray absorptiometry (DXA) in patients on hydrocortisone or prednisolone at baseline,6month and 1 year.Timepoint: one year