The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- AUC post prandial glucose concentration
Study Overview
Brief Summary
The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.
Detailed Description
Fifteen (n=15) sedentary adult overweight males will be included in the study. All participants will undergo the four interventions in a randomized cross-over design. Wash out between intervention will be minimum four days.
Control (CON): Participants will be sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.), with a target MET below 1.5 (i.e. 1.5 times REE). Participants will only be allowed to stand or walk to go to the toilet.
Breaker: Participants will be breaking up prolonged sitting with 2 min intervals of low intensity walking.
Intermediate: Participants will be breaking up prolonged sitting with 6 min intervals of low intensity walking
Prolonger: Participants will be breaking up prolonged sitting with 12 min intervals of low intensity walking
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 50 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Males, age 20-50 years, waist-to-height ratio ≥ 0.5 and/or waist circumference ≥ 102 cm.
Exclusion Criteria
- •Clinically diagnosed diabetes, uncontrolled hypertension, use of glucose- and/or lipid-lowering medication, smoking, evidence of thyroid, liver, lung, heart or kidney disease, non-sedentary occupation, and VO2max levels above the considered average fitness according to age (Shvartz & Reibold 1990), contraindications to increased levels of physical activity.
Arms & Interventions
Control
Participants will spend 8 hours sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.) Participants will only be allowed to stand or walk to go to the toilet.
Intervention: Control (Behavioral)
Breaker
Participants will spend a total of 7 hours and 12 min sedentary and a total of 48 min breaking sitting time with LPA. Sedentary time will be done in bouts of 18 min with 2 min of light walking.
Intervention: Breaker (Behavioral)
Intermediate
Total duration of sedentary time and LPA time will be the same as in Breaker. Sedentary time will be done in bouts of 54 min with 6 min of LPA between each bout.
Intervention: Intermediate (Behavioral)
Prolonger
Total duration of sedentary time and LPA time will be the same as in Breaker. Sedentary time will be done in bouts of 108 min with 12 min of LPA between each bout.
Intervention: Prolonger (Behavioral)
Outcomes
Primary Outcomes
AUC post prandial glucose concentration
Time Frame: 6 hours
Secondary Outcomes
- AUC post prandial hdl concentration(6 hours)
- Mean 24 hour glucose concentration(24 hours)
- AUC post prandial insulin concentration(6 hours)
- AUC post prandial c-peptide concentration(6 hours)
- AUC post prandial glucagon concentration(6 hours)
- Variation in 24 hour glucose concentration(24 hours)
- AUC post prandial triglyceride concentration(6 hours)
- AUC post prandial ldl concentration(6 hours)
- AUC post prandial total cholesterol concentration(6 hours)
- Maximum in 24 hour glucose concentration(24 hours)
Investigators
Mathias Ried-Larsen
Group leader
Rigshospitalet, Denmark