Effect of Frequent Interruptions of Prolonged Sitting on Self-perceived Levels of Energy, Mood, Food Cravings and Cognitive Function
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 30
- Primary Endpoint
- Change in Cognitive function
Study Overview
Brief Summary
This study is designed to test the effects of six 5 minute microbursts of physical activity spread across the day as compared to either a sedentary control condition or a single 30 minute bout of moderate intensity physical activity on cognitive function, self-reported energy levels, aspects of eating behavior and measures of metabolic health. The primary hypotheses are:
- Hourly 5 minute bouts of moderate intensity exercise during the day will increase afternoon cognitive function as compared to a no exercise condition.
- Hourly 5 minute bouts of moderate intensity exercise during the day will increase afternoon cognitive function more than a single 30 minute AM bout.
Secondary exploratory hypotheses include
- Hourly 5 minute bouts of moderate intensity exercise during the day will increase self-reported energy levels, reduce orexigenic appetitive measures and improve measures of metabolic health as compared to a no exercise condition.
- Hourly 5 minute bouts of moderate intensity exercise during the day will increase self-reported energy levels, reduce orexigenic appetitive measures and improve measures of metabolic health more than a single 30 minute AM bout.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 19 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •All ethnic groups and both genders
- •Age: Lower age limit: 19 years; Upper age limit: 45 years
- •Body-mass Index: Lower BMI limit: 18.5 kg/m2; Upper BMI limit: 29.9 kg/m2
- •Willing to adhere to caffeine restrictions of no more than two 16 ounce beverages in the morning of each study day with no caffeine intake after 12:00pm on any of the three study days
Exclusion Criteria
- •History of cardiovascular disease, including coronary artery disease, congestive heart failure, & unstable angina, or uncontrolled hypertension (>140/90 mm Hg)
- •Currently smoking or stopped smoking in the last 6 months
- •Medications affecting weight, energy intake, or energy expenditure in the last 6 months
- •Use of oral steroids
- •History of stroke or seizures, thyroid disease, type 1 or 2 diabetes, Cushing's syndrome, cerebrovascular, renal disease, hepatic disease, arrhythmias
- •Cancer requiring treatment in the past 5 years, with the exception of skin cancers other than melanoma
- •Infectious diseases: Self-reported HIV positivity or active tuberculosis
- •Inability to exercise for more than 30 minutes on a treadmill at moderate intensity
- •Currently pregnant, lactating or less than 6 months post-partum
- •History of a major psychiatric disorder including schizophrenia, bipolar illness or psychotic depression
- •Score of >25 on Beck Depression Inventory
- •No recreational drug use including marijuana in the past 1 year
Arms & Interventions
Uninterrupted sitting
Subjects remained seated all day except to rise from the chair to void.
Sitting + one bout of activity
Subjects remained seated all day, except to rise from the chair to void, and to perform one bout of 30-minutes moderate-intensity walking. Physical activity was performed at 0800, after measures of vitals and basal questionnaire assessments, but before breakfast.
Intervention: physical activity (Behavioral)
Sitting + microbursts of activity
Subjects rose from the seated position every hour for 6-hours from 0910 to 1430 to complete 5-minute bouts of moderate-intensity walking, yielding a total activity time of 30-minutes.
Intervention: physical activity (Behavioral)
Outcomes
Primary Outcomes
Change in Cognitive function
Time Frame: During each of the three separate study days cognitive function is measured at (in minutes): T410
The flanker task is used to measure cognitive function
Change in Cognitive Function
Time Frame: During each of the three separate study days cognitive function is measured at (in minutes): T425
After the Flanker task, the Comprehensive Trail Making Test is used to measure cognitive function during each study day.
Change in Energy and Mood level
Time Frame: During each of the three separate study days energy and mood levels are assessed at (in minutes): T0, T40, T70, T80, T90, T120, T140, T230, T350, T390, T400, T405, T410, and T435
Self-perceived energy and mood were measured by using visual analogue scales (VAS) as described below at baseline.
Secondary Outcomes
No secondary outcomes reported