A study to assess the efficacy of preoperative IV Tranexenamic acid in reducing intraoperative blood loss in cancer patients
- Conditions
- Malignant neoplasm of breast, (2) ICD-10 Condition: C15-C26||Malignant neoplasms of digestive organs, (3) ICD-10 Condition: C51-C58||Malignant neoplasms of female genital organs, (4) ICD-10 Condition: C00-C14||Malignant neoplasms of lip, oral cavity and pharynx, (5) ICD-10 Condition: C45-C49||Malignant neoplasms of mesothelial and soft tissue, (6) ICD-10 Condition: O||Medical and Surgical, (7) ICD-10 Condition: C00-D49||Neoplasms,
- Registration Number
- CTRI/2023/03/050390
- Brief Summary
To determine the impact of preoperative administration of tranexamic acid on
1. Intra-operative blood loss and
2. transfusion rates
in major oncological surgeries
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 120
all cancer patients undergoing surgeries for breast gyanecology, Head &neck ,GI, soft tissue sarcoma& others.
Patients with coagulopathy(activated partial thromboplastin time >50 s or International normalised ratio >1.5, platelets <50 X 109/L), Recent history of acetylsalicylic acid ingestion (< 5 days), Patients on anticoagulation therapy (received heparin within 4 hours or received warfarin 3 days preoperatively), Those with known peripheral vascular disease, Pre-existing renal dysfunction (serum creatinine >1.2 mg/dl), Liver dysfunction, Known allergy to tranexamic acid.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Operative blood loss baseline 2. Blood transfusion rates baseline
- Secondary Outcome Measures
Name Time Method 1.Length of hospital stay 2.Length of stay in ICU
Trial Locations
- Locations (1)
Tirunelveli medical college Hospital
🇮🇳Tirunelveli, TAMIL NADU, India
Tirunelveli medical college Hospital🇮🇳Tirunelveli, TAMIL NADU, IndiaDEEPAPrincipal investigator9500018478oncodeepa@gmail.com