Efficacy of Oral Ivabradine in Patients Presenting With NSTEMI
- Registration Number
- NCT04285736
- Lead Sponsor
- Cairo University
- Brief Summary
This study aims to evaluate the beneficial effect of heart rate reduction of oral ivabradine in patients presenting with non ST-segment elevation myocardial infarction (NSTEMI) during acute stage post percutaneous coronary intervention versus conventional treatment.
Materials and methods: A total of 100 patients admitted to the emergency department, National Heart Institute, Cairo, Egypt were randomized into two groups as follows: Group A: 50 patients with NSTEMI treated with ivabradine (5mg twice daily) in addition to the conventional treatment; Group B: 50 patients with NSTEMI treated with the conventional treatment only. Demographic data, detailed history, clinical examination, chest pain onset, blood pressure, heart rate (HR), temperature and respiratory rate, electrocardiogram (ECG) as well as echocardiography and laboratory investigations were recorded. Patients were monitored for a period of 3-5 days (acute stage).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- Patients with NSTEMI with normal sinus rhythm and heart rate (HR) more than 70 beats per minute (bpm) and systolic blood pressure (SBP) >90 mm Hg undergoing PCI
- Patients needing urgent cardiac surgery, IV inotropic agents or had a HR less than 60 bpm without any medication.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group B Control Group Ivabradine - Group A Ivabradine Group Ivabradine - Group B Control Group Conventional Treatment -
- Primary Outcome Measures
Name Time Method Heart Rate acute stage post percutaneous coronary intervention (3-5 days) Heart Rate Reduction
- Secondary Outcome Measures
Name Time Method