Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males

Not Applicable

Completed

• Conditions: Dietary Supplementation
• Interventions: Dietary Supplement: Grape seed extract; Dietary Supplement: Placebo

• Registration Number: NCT05116150
• Lead Sponsor: California Baptist University

Brief Summary

This study was to examine the additive benefits with combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study.

Detailed Description

The investigators aimed the additive effects of combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study. Effects of 7 days of combined GSE with L-citrulline supplementation on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), cardiac output (CO), total vascular conductance (TVC), and oxygen consumption (O2) were examined at rest and during cycling exercise.

Study Timeline

• Study Start: 2019-06-01
• Primary Completion: 2019-12-01
• Study Completion: 2019-12-01
• Study First Submitted: 2021-10-19
• Status Verified: 2021-11
• Study First Submitted QC: 2021-11-01
• Last Update Submitted: 2021-11-01
• Study First Posted: 2021-11-10
• Last Update Posted: 2021-11-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 11

Inclusion Criteria

• healthy males

Exclusion Criteria

• cardiovascular and/or pulmonary disease, musculoskeletal disorders, or medications that prevent the safe completion of the exercise protocol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Randomized double blind placebo design	Placebo	Placebo
Randomized double blind grape seed extract design	Placebo	Grape see extract
Randomized double blind grape seed extract design	Grape seed extract	Grape see extract
Randomized double blind placebo design	Grape seed extract	Placebo

Primary Outcome Measures

Name	Time	Method
Systolic blood pressure (mmHg)	7 days	by sphygmomanometer
Diastolic blood pressure (mmHg)	7 days	by sphygmomanometer
Mean arterial pressure (mmHg)	7 days	calculated (MAP = (SBP-DBP)/3 + DBP
Heart rate (bpm)	7 days	measured using Physio Flow (non-invasive device)
Stroke volume (ml)	7 days	measured using Physio Flow (non-invasive device)
Cardiac output (l/min)	7 days	calculated: HR (bpm) x SV (ml)
Total vascular conductance (ml/min/mmHg)	7 days	calculated: CO (ml/min) / MAP (mmHg)

Trial Locations

Locations (1)

California Baptist University; 🇺🇸 Riverside, California, United States