To study the effect of antiretroviral drugs on ageing and immunity in children living with HIV
Not Applicable
- Conditions
- Health Condition 1: B20- Human immunodeficiency virus [HIV]disease
- Registration Number
- CTRI/2023/05/052950
- Lead Sponsor
- intramural research grant for pg thesis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Group 1: ART-naïve CLHIV, Group 2: CLHIV on ART (for >=1y duration on current ART regimen), Group 3: Age-matched healthy controls
Exclusion Criteria
Poor adherence to ART ( <95%), immunological failure, critically-ill children, those with clinically proven opportunistic infections (OIs) like TB, CMV, HCV and HBV infection, those with chronic diseases like chronic liver disorders or renal insufficiency, those receiving antibiotics or steroids >=1month duration, anti-tuberculous/ isoniazid preventive therapy (IPT), CLHIV on second line ART (virological failure) and those receiving immunomodulators or anti-oxidant supplements within the preceding 3 months
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Telomere lengthTimepoint: 18 months
- Secondary Outcome Measures
Name Time Method T-cell receptor rearrangement excision circles (TREC) levels, <br/ ><br>CD4 counts,Correlation between TL, TREC levels and CD4 counts and the duration of ART, HIV viral load, and age at starting ART <br/ ><br>Timepoint: 18 months