Quantifying stimulus evoked electroencephalographic variability in mild dementia

Not Applicable

Recruiting

• Conditions: Dementia; Alzheimer's Disease; Neurological - Dementias; Neurological - Alzheimer's disease

• Registration Number: ACTRN12623000285651
• Lead Sponsor: St Vincent's Hospital Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-16
• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Male and female participants 60 years or older

English speaking and basic levels of literacy in order to be able to give informed consent and to follow all instructions

Normal or corrected hearing and vision

CN group: Formally assessed to be cognitively normal by CADMS Neuropsychiatrist

MDAD group: Formal diagnosis by CADMS Neuropsychiatrist of possible or probable Alzheimer's Disease; Mild dementia as defined by Clinical Dementia Rating score of 0.5 - 1, Global Deterioration Scale score of 4, and Min-mental Status Examination score of 18 - 23

Exclusion Criteria

Colour blindness

Any history of illness affecting cognitive function e.g., vitamin B12 deficiency, hypothyroidism, significant psychiatric disorders (such as major depression or schizophrenia), neurodegenerative disorders, ischaemic stroke, epilepsy, brain tumour, significant head trauma

Any episodes of unexplained loss of consciousness

History of substance or alcohol abuse

Taking an acetylcholinesterase inhibitor, or any other agent demonstrated to affect cognitive function, within the last 3 months

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time course of time locked changes in evoked EEG variability during the visual semantic priming task[ During the single EEG recording session];Time course of time locked changes in evoked EEG variability during the passive visual memory repetition priming task[ During the single EEG recording session];Time course of time locked changes in evoked EEG variability during the active three level auditory oddball task[ During the single EEG recording session]

Secondary Outcome Measures

Name	Time	Method
Eyes-open resting state EEG band powers[ During the single EEG recording session];Eyes-closed resting state EEG band powers[ During the single EEG recording session]