Machine Learning-based Model for Prediction of Survival and Mutations in Ovarian Metastases of Colorectal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Disease-free survival
研究概览
简要总结
The study aimed to develop and validate models to predict survival outcome and key mutations in patients with ovarian metastases of colorectal cancer, as well as to compare the differential gene expression between long-survival group and short-survival group.
详细描述
The investigator performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict survival outcome and key mutations from multimodality data in patients with ovarian metastases of colorectal cancer. Secondly, the investigator aimed to compare the differential gene expression between long-survival group and short-survival group.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed colorectal cancer
- •Unilateral or bilateral ovarian masses confirmed by peroperative imaging examination
- •Patient requiring resection of their ovarian and/or peritoneal carcinomatosis
- •18 ≤ Age ≤ 85
- •World Health Organization performance status ≤ 1
- •Life expectancy > 12 weeks
- •Adequate haematological, liver and renal function
- •Patient information and signature of the informed consent form before the start of any treatment procedures
排除标准
- •Ovarian metastases of origin other than colorectal
- •Primary ovarian tumor
- •Clinical data missing
结局指标
主要结局
Disease-free survival
时间窗: At least 1-year follow up
Disease-free survival was defined as the interval between surgery and the first peritoneal or distant relapse or death from any cause.
Peritoneal-free survival
时间窗: At least 1-year follow up
Peritoneal-free survival was defined as the interval between surgery and the first peritoneal relapse. Ovarian metastasis has been shown to be a subtype of peritoneal metastasis.
Overall survival
时间窗: At least 3-year follow up
Overall survival was defined as the time from surgery to death, or to the last follow-up.
次要结局
- Rates of key gene mutation(At least 1-year follow up)