Machine Learning-based Model for Prediction of Survival and Mutations in Ovarian Metastases of Colorectal Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ovarian Metastases of Colorectal Cancer
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Disease-free survival
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The study aimed to develop and validate models to predict survival outcome and key mutations in patients with ovarian metastases of colorectal cancer, as well as to compare the differential gene expression between long-survival group and short-survival group.
Detailed Description
The investigator performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict survival outcome and key mutations from multimodality data in patients with ovarian metastases of colorectal cancer. Secondly, the investigator aimed to compare the differential gene expression between long-survival group and short-survival group.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Histologically confirmed colorectal cancer
- •Unilateral or bilateral ovarian masses confirmed by peroperative imaging examination
- •Patient requiring resection of their ovarian and/or peritoneal carcinomatosis
- •18 ≤ Age ≤ 85
- •World Health Organization performance status ≤ 1
- •Life expectancy \> 12 weeks
- •Adequate haematological, liver and renal function
- •Patient information and signature of the informed consent form before the start of any treatment procedures
Exclusion Criteria
- •Ovarian metastases of origin other than colorectal
- •Primary ovarian tumor
- •Clinical data missing
Outcomes
Primary Outcomes
Disease-free survival
Time Frame: At least 1-year follow up
Disease-free survival was defined as the interval between surgery and the first peritoneal or distant relapse or death from any cause.
Peritoneal-free survival
Time Frame: At least 1-year follow up
Peritoneal-free survival was defined as the interval between surgery and the first peritoneal relapse. Ovarian metastasis has been shown to be a subtype of peritoneal metastasis.
Overall survival
Time Frame: At least 3-year follow up
Overall survival was defined as the time from surgery to death, or to the last follow-up.
Secondary Outcomes
- Rates of key gene mutation(At least 1-year follow up)