Emotional Brain Networks & Cognitive Functioning in Depression and Anxiety

• Conditions: Major Depressive Disorder; General Anxiety Disorder

• Registration Number: NCT03084042
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

This study aims to 1) examine common and specific emotional and cognitive dysfunctions between Major Depression and generalized anxiety disorder; 2) Examine emotional and cognitive dysfunctions between the two disorders and healthy controls; 3) Examine the biomarkers predicting successful therapy or not.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-07
• Study First Submitted: 2017-02-24
• Study First Submitted QC: 2017-03-13
• Study First Posted: 2017-03-20
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-26
• Last Update Posted: 2018-10-29
• Primary Completion: 2018-12
• Study Completion: 2019-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

• GAD:

  1. Diagnosis of Generalized Anxiety Disorder (GAD) according to DSM V criteria in a structured clinical interview for DSM-V Axis I disorders (SCID I; APA, 2014) and a confirmatory clinical interview
  2. Duration of the current episode > 3 weeks

• MDD:

  1. Diagnosis of current major depressive disorder in a structured clinical interview for DSM-V Axis I disorders (SCID I; APA, 2014) and a confirmatory clinical interview
  2. Duration of the current episode > 4 weeks

Exclusion Criteria

• GAD: diagnosis of any other psychiatric Axis I disorder (except GAD) as a principal diagnosis within the past six months
• MDD: diagnosis of any other psychiatric Axis I disorder (except MDD) as a principal diagnosis within the past six months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain activity in the emotional and cognitive core regions of the brain as assessed by fMRI	1 hour (assessed at study inclusion)	fMRI based indices during working memory

Secondary Outcome Measures

Name	Time	Method
Behavioral performance during the fMRI: working memory	1 hour (assessed at study inclusion)	Working memory performance during fMRI
Symptom improvement after 3 months: depression	3 months	Symptoms of depression will be assessed using validated clinical scales (e.g. BDI)
Behavioral performance during the fMRI: face processing	1 hour (assessed at study inclusion)	Accuracy during face processing
Behavioral performance during the fMRI: empathy reactivity	1 hour (assessed at study inclusion)	Empathy in response to empathy inducing pictures (rated on Likert scale)
Cognitive performance at study inclusion	1 hour (assessed at study inclusion)	Executive functions as assessed via computerized tests (CANTAB)
Symptom improvement after 3 months: anxiety	3 months	Symptoms of generalized anxiety will be assessed using validated clinical scales (e.g. Penn State Worry Questionnaire)

Trial Locations

Locations (1)

School of Life Science and Technology, University of Electronic Science and Technology of China; 🇨🇳 Chendu, Sichuan, China

School of Life Science and Technology, University of Electronic Science and Technology of China

🇨🇳Chendu, Sichuan, China

Benjamin Becker, Dr.

Contact

ben_becker@gmx.de