NCT03453242终止不适用
Age Influence on Cortical Bone Measured by Ultrasound
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Cortical parameters measurement
研究概览
简要总结
The study of this study is to evaluate the age influence on cortical bone strength properties by two methods:HR-pQCT (HighResolution-peripheral quantitativeComputedTomography) and ultrasound. The main objective consists in the evaluation of the age influence on cortical thickness at 1/3 distal radius measured by US.
详细描述
The study of this study is to evaluate the age influence on cortical bone by two methods: HR-pQCT and ultrasound.
84 patients will be measured. The cohort will be:
- 21 women less than 70
- 21 women more than 70
- 21 men less than 70
- 21 men more than 70 Measurement will be performed at radius and at tibia (ultra-distal and distal). For all the sites one measurement will be performed by HR-pQCT to get reference values of thickness and BMDs. For the distal positions and additional measurement will be performed by an innovative ultrasound device that estimates cortical thickness and porosity.
The participation to the study implies only a participation of one hour from the patient (30min for HR-pQCT measurements, 30 min for US).
The main objectives consist in :
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •being 18 or older
- •coming from the rheumatology consultation at Lariboisière Hospital
排除标准
- •BMI > 28
- •BMI < 15
- •cortisone treatment
- •recent fracture at non-dominant arm
- •wound on measuring zone
- •treatment interfering with bone architecture or bone density : oral of transdermic oestrogenes, bisphosphonates (Alendronate, Risedronate, Zoledronate) or Denosumab during the past 6 months-
结局指标
主要结局
Cortical parameters measurement
时间窗: Inclusion time
Cortical thickness at distal radius 1/3
次要结局
- Tibia parameters measurement by HR-pQCT(Inclusion time)
- Porosity measurement(Inclusion time)
- Cortical parameters measurement(Inclusion time)
- Tibia parameters measurement by US(Inclusion time)
- Thicknesses measurement(Inclusion time)
- vBMD measurement(Inclusion time)
- Ultra-distal vBMD measurement(Inclusion time)
研究者
研究点 (1)
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