A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram

Terminated

• Conditions: Obstructive Sleep Apnea; Cardiac Syndrome X; Endothelial Dysfunction
• Interventions: Other: no intervention is involved in this study

• Registration Number: NCT01217346
• Lead Sponsor: The University of Hong Kong

Brief Summary

Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction. Endothelial dysfunction is also reported to be linked to obstructive sleep apnea. While chest pain can be one of potential presenting symptoms of obstructive sleep apnea, the investigators hypothesize that obstructive sleep apnea is common in subjects with cardiac syndrome X.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-02
• Study First Submitted: 2010-10-04
• Study First Submitted QC: 2010-10-07
• Study First Posted: 2010-10-08
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Status Verified: 2013-08
• Last Update Submitted: 2013-08-01
• Last Update Posted: 2013-08-02

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age ≧18 years, < 70 years
• Symptom of chest pain occurring at least once in the preceding year
• Positive exercise treadmill test
• Negative coronary angiogram
• Mentally fit to give informed consent

Exclusion Criteria

• Mentally incapacitated persons
• Congestive heart failure
• Other potential causes of orthopnea (severe chronic obstructive pulmonary disease, persistent asthma)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cardiac syndrome X	no intervention is involved in this study	subjects fulfilling the clinical triad of cardiac syndrome X

Primary Outcome Measures

Name	Time	Method
apnea hypopnea index	measure at a single time point when the subjects are admitted for overnight polysomnography	assess apnea hypopnea index by overnight polysomnography, by a single admission to sleep laboratory

Secondary Outcome Measures

Name	Time	Method
endothelial function	measured at a single time point when the subjects are admitted for overnight polysomnography	assess endothelial function by EndoPAT 2000 (an non-invasive device) and peripheral blood endothelial progenitor cells

Trial Locations

Locations (1)

Queen Mary Hospital, The University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong