RELIEF - Resistance Training for Life
- Conditions
- Sarcopenia
- Interventions
- Other: Progressive resistance training
- Registration Number
- NCT05063279
- Lead Sponsor
- Stian Ellefsen
- Brief Summary
Sarcopenia is an age-related gradual loss of muscle mass and strength and is associated with physical disability and mortality risk. Currently, the most promising remedy for preventing and treating sarcopenia is physical activity, particularly progressive resistance training. Yet, the amount of resistance exercise needed to achieve optimal benefits remains largely unknown. This lack of knowledge is underpinned by the notion that aging reduces the ability to adapt to (and benefit from) resistance training, and is further complicated by a relative large degrees of between-subject heterogeneity. The primary aim of the study is to compare the effects of 10 weeks of resistance training with low- and moderate volume (one vs. three sets per exercise) on muscle mass accretion in lower and upper body extremities in young (\<30 years of age) and elderly individuals (\>70 years of age). Specifically, the study addresses the hypothesis that elderly individuals will benefit more from higher exercise volume (moderate vs. low) compared to their young counterparts. In addition, the study aims to compare the efficacy of the two volume conditions for altering other characteristics such as muscle strength and biology, including assessment of associations between individual changes in muscle mass, strength and biology (e.g. the relationship between muscle mass accretion and muscle content of rRNA/rDNA), and also to investigate the general health effects of the intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 76
- Ages between 18 and 30 or > 70
- Resistance training, > 1 session per week
- Endurance training, > 3 sessions per week
- Unstable cardiovascular disease
- Illness or serious injury contradicting resistance training
- Serious mental illness
- Allergy to local anaesthesia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Resistance training group Progressive resistance training Participants in two age groups will receive moderate (three sets of per exercise per session) and low-volume (one set of resistance per session) training allocated to either right or left upper- and lower extremities. A total of 24 sessions will be performed over 10-12 weeks.
- Primary Outcome Measures
Name Time Method Muscle size, lower extremities Change from baseline to after the training period (10-12 weeks) Muscle size of lower extremity knee extensors measured with magnetic resonance imaging (MRI).
- Secondary Outcome Measures
Name Time Method Muscular peak power/force, lower-body extremities MeasurChange from baseline to after the training period (10-12 weeks) Muscular peak power/force measured using dynamic leg press
Muscle size, upper-body extremities Change from baseline to after the training period (10-12 weeks) Muscle size of upper extremity elbow flexors measured with magnetic resonance imaging (MRI).
Appendicular lean mass, lower-body extremities Change from baseline to after the training period (10-12 weeks) Appendicular lean mass of the legs measured using Dual X-Ray Absorptiometry
Appendicular lean mass, upper-body extremities Change from baseline to after the training period (10-12 weeks) Appendicular lean mass of the arms measured using Dual X-Ray Absorptiometry
Muscle thickness, m. vastus lateralis Change from baseline to after the training period (10-12 weeks) Musle thickness of m. vastus lateralis measured using ultrasound
Muscle strength, lower-body extremities Change from baseline to after the training period (10-12 weeks) Muscle strength of the legs measured as a weighted average of lower body isokinetic and isometric knee extensor maximal force
Muscle strength, upper-body extremities Change from baseline to after the training period (10-12 weeks) Muscle strength of the arms measured as isometric force (elbow flexors; fixed angle)
Trial Locations
- Locations (1)
Inland Norway University of Applied Sciences
🇳🇴Lillehammer, Norway