ISRCTN26119679
Completed
未知
A double blind randomised controlled trial of post-operative low molecular weight heparin bridging therapy versus placebo bridging therapy for patients who are at high risk for arterial thromboembolism
ondon Health Sciences Centre (Canada)0 sites1,773 target enrollmentJune 4, 2008
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Arterial thromboembolism
- Sponsor
- ondon Health Sciences Centre (Canada)
- Enrollment
- 1773
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
2018 results in: https://ash.confex.com/ash/2018/webprogram/Paper109964.html (added 19/02/2019)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Informed consent
- •2\. Patients of either sex, 18 years and older, with prosthetic heart valves receiving long\-term oral anticoagulation with warfarin, or
- •3\. Patients with atrial fibrillation and a major risk factor (previous transient ischaemic attack (TIA) or stroke, high blood pressure, diabetes, 75 years and older, moderate/severe left ventricle dysfunction), who require elective non\-cardiac surgery or an invasive procedure with reversal of their anticoagulant therapy
Exclusion Criteria
- •1\. Evidence of active bleeding prior to stopping warfarin
- •2\. Platelet count less than 100 x 10^9/L
- •3\. Spinal or neurosurgery
- •4\. Life expectancy less than three months
- •5\. Serum creatinine greater than 150 umol/L
- •6\. Patients requiring cardiac surgery
- •7\. Multiple prosthetic valves or Starr\-Edwards valves or prosthetic valves with a history of stroke or TIA
Outcomes
Primary Outcomes
Not specified
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