CMR Features in Patients With Suspected Myocarditis
- Conditions
- Outcome, Fatal
- Registration Number
- NCT03470571
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
Presentation of myocarditis is heterogeneous, often ranges from being asymptomatic, to chest pain, dyspnoea, palpitations, and even sudden cardiac death. Diagnosing myocarditis is challenging with no current uniform clinical gold-standard. CMR is a key investigative tool, however the predictive value of CMR features is unknown. In this study we assess 670 consecutive patients with suspected myocarditis who were referred for CMR between 2002 and 2015 at the BWH. CMR features such as late gadolinium sizing, T1 mapping, extracellular volume fraction assessment, strain analysis (feature tracking), clinical data, labortory tetsings and electrocardiogramm are linked to the outcome in order to assess its predictive value.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 670
- patients referred by their treating physician to undergo CMR for "suspected myocarditis" as the primary clinical question
Exclusion criteria
- evidence of coronary artery disease
- hypertrophic cardiomyopathy
- arrhythmogenic right ventricular cardiomyopathy
- cardiac sarcoidosis
- cardiac amyloidosis
- takotsubo cardiomyopathy
- constrictive pericarditis
- Loeffler endocarditis
- ventricular non-compaction
- cardiac tumor
- pulmonary embolism
- severe valve disease
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Major adverse cardiac events through study completion, an average of 2 years Heart failure hospitalization; all cause death; sustained ventricular arrhythmia; recurrent myocarditis; transplantation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Brigham and Women's Hospital, Shapiro Cardiovascular Center
🇺🇸Boston, Massachusetts, United States