Assessing heart problems in psoriasis patients using cardiovascular magnetic resonance (CMR) imaging

Not Applicable

Completed

Conditions: Myocardial involvement in patients with psoriasis.
Skin and Connective Tissue Diseases

Registration Number: ISRCTN71534700

Lead Sponsor: Charité - Universitätsmedizin Berlin

Brief Summary: 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38753001/ (added 21/05/2024)

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 64

Inclusion Criteria

1. Signed consent
2. Age =18 years (no upper limit)
3. Verified psoriasis without any of the pre-existing conditions listed under exclusion criteria

Exclusion Criteria

1. Absolute contraindication for MRI examination
2. Severe previous cardiac disease in particular: Condition after myocardial infarction, Condition after CABG (aorto-coronary vein bypass), Coronary artery disease with or without condition after intervention (stenting)
3. Known allergy to MRI contrast agents
4. Chronic kidney disease with GFR <30ml/min (after CKD-EPI)
5. Pregnancy, lactation

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Myocardial T1 and T2 times determined by mapping techniques and detection and size of myocardial focal fibrosis by late gadolinium enhancement techniques and extracellular volume (ECV) by applying CMR once (single timepoint).

Secondary Outcome Measures

Name	Time	Method
1. Quantitative cardiac parameters regarding function, dimension and mass of the ventricles and atria using cine-imaging techniques by applying CMR once (single timepoint). <br>2. Analysis of function by measuring cardiac deformation (strain) to determine longitudinal, circumferential and radial strain by applying CMR once (single timepoint). <br>