Substrate and mechanisms of ventricular arrhythmia in non-ischemic cardiomyopathy - Non-ischemic cardiomyopathy

eids Universitair Medisch Centrum0 个研究点目标入组 220 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•A) NICM patients with
•- documented VA or
•- suspected VA (e.g. because of out-of-hospital cardiac arrest, palpitations or syncope) or
•- high risk for VA (LVEF * 35% and NYHA functional class II or III*) or
•- intermediate risk for VA (LVEF * 50%* and late enhancement on CE-MRI)
•who are not admitted for cardiac surgery;B) NICM patients with
•- documented VA or
•- suspected VA (e.g. because of out-of-hospital cardiac arrest, palpitations or syncope) or
•- high risk for VA (LVEF * 35% and NYHA functional class II or III*)
•who are admitted for cardiac surgery (e.g., mitral valve annuloplasty or CorCap)
•C) Non-NICM patients (controls) who are admitted for
•- Coronary artery bypass graft surgery and who do not have prior myocardial infarction.
•- Aortic valve replacement.

•Exclusion criteria are as follows:;- Age < 18 years or > 80 years
•- Inadequate patient competence
•- Pregnancy
•- Inability to comply with the protocol due to haemodynamic instability
•- Non-NICM (e.g., prior myocardial infarction, infiltrative cardiac disease such as sarciodosis, amyloidosis or Chagas cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy/dysplasia, hypertrophic cardiomyopathy, non-compaction cardiomyopathy and congenital heart disease);Exclusion criteria for CE-MRI:
•- According to the safety guidelines for MR-imaging. These can be found on Albinusnet: MRI / Veiligheidsrichtlijnen voor MR-imaging, http://albinusnet.lumc.nl/home/reg/pro/1010/60711030322284).;Exclusion criteria for blood sampling:
•- Haemoglobin < 6.0 mmol/L

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