GEnetic causes of Ventricular Arrhythmias in patients with first STEMI (GEVAMI) study

niversity Hospital of Copenhagen0 个研究点目标入组 3,000 人开始时间: 2016年12月2日最近更新: 2017年10月16日

适应症

试验速览

暂无简介。

•1. First STEMI patients who experienced VF within the first 12 hours of symptoms of STEMI before PPCI
•2. Age between 18 and 80 years
•3. Caucasians
•4. Cardiac symptoms lasting =12 hours
•5. Acute ST-segment elevation revealed by ECG
•1. First STEMI patients who did not have VF during the first 12 hours of symptoms of STEMI before PPCI
•2. Age between 18 and 80 years
•3. Caucasians
•4. Cardiac symptoms lasting =12 hours
•5. Acute ST-segment elevation revealed by ECG

•1. Cases and controls who developed VF during PPCI will be excluded because VF during PPCI is believed to be reperfusion induced; however, case patients with VF before PPCI who continued to have VF during PPCI can participate
•2. Other exclusions included VF after PPCI
•3. Congenital heart defects
•4. Known structural heart disease
•5. Use of class I and III antiarrhythmic drugs
•6. Recent cancer
•7. Major surgery or trauma within 4 weeks
•8. Presentation with potassium concentration of <3 or >5 mmol/L
•9. Because we also planned to identify genetic markers associated with VF, and because >90% of the Danish populations are white Danes, we excluded non-white Danes to reduce the risk of population stratification for future genetic analysis

发起方

niversity Hospital of Copenhagen