ISRCTN17749344
Recruiting
Not Applicable
GEnetic causes of Ventricular Arrhythmias in patients with first STEMI (GEVAMI) study
niversity Hospital of Copenhagen0 sites3,000 target enrollmentDecember 2, 2016
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ventricular fibrillation
- Sponsor
- niversity Hospital of Copenhagen
- Enrollment
- 3000
- Status
- Recruiting
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. First STEMI patients who experienced VF within the first 12 hours of symptoms of STEMI before PPCI
- •2\. Age between 18 and 80 years
- •3\. Caucasians
- •4\. Cardiac symptoms lasting \=12 hours
- •5\. Acute ST\-segment elevation revealed by ECG
- •1\. First STEMI patients who did not have VF during the first 12 hours of symptoms of STEMI before PPCI
- •2\. Age between 18 and 80 years
- •3\. Caucasians
- •4\. Cardiac symptoms lasting \=12 hours
- •5\. Acute ST\-segment elevation revealed by ECG
Exclusion Criteria
- •1\. Cases and controls who developed VF during PPCI will be excluded because VF during PPCI is believed to be reperfusion induced; however, case patients with VF before PPCI who continued to have VF during PPCI can participate
- •2\. Other exclusions included VF after PPCI
- •3\. Congenital heart defects
- •4\. Known structural heart disease
- •5\. Use of class I and III antiarrhythmic drugs
- •6\. Recent cancer
- •7\. Major surgery or trauma within 4 weeks
- •8\. Presentation with potassium concentration of \<3 or \>5 mmol/L
- •9\. Because we also planned to identify genetic markers associated with VF, and because \>90% of the Danish populations are white Danes, we excluded non\-white Danes to reduce the risk of population stratification for future genetic analysis
Outcomes
Primary Outcomes
Not specified
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