Energetic Abnormalities in Heart Failure With Preserved Ejection Fraction
- Conditions
- Heart Failure, Diastolic
- Registration Number
- NCT00628082
- Lead Sponsor
- University Hospital Birmingham
- Brief Summary
Up to half of all patients with heart failure are found to have normal pumping function of the heart muscle, but show abnormalities in the way the heart muscle relaxes and fills with blood. These patients often have high blood pressure, and tend to have stiff arteries and stiff heart muscle. We wish to test the hypothesis that these patients have abnormal energy stores in their heart muscle.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Clinical features consistent with heart failure
- LVEF ≥ 50%, with no evidence of significant valvular disease, no hypertrophic cardiomyopathy, and no evidence of pericardial constriction
- A peak VO2 < 80% predicted, with a pattern of gas exchange on metabolic exercise testing indicating a cardiac cause for limitation
Exclusion Criteria
- Objective evidence of lung disease on formal lung function testing
- Reversible myocardial ischaemia on contrast-enhanced myocardial stress
- Echocardiography, and evidence of exercise-induced mitral regurgitation
- Obesity (BMI >35) or a locomotor cause for exercise limitation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Complete echocardiographic assessment to assess resting diastolic function 1 DAY Assessment of resting large artery function 1 DAY Multiple Gated Acquisition Scan 1 DAY Cardiac Magnetic Resonance Spectroscopy 1 DAY Metabolic Exercise Testing (VO2max) 1 DAY
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Birmingham
🇬🇧Birmingham, United Kingdom