Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms

Phase 4

Completed

• Conditions: Schizophrenia
• Interventions: Drug: placebo; Drug: memantine

• Registration Number: NCT00757978
• Lead Sponsor: Hospital de Clinicas de Porto Alegre

Brief Summary

Memantine as an add-on therapy to clozapine may improve schizophrenia negative symptoms and cognitive functioning.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01
• Primary Completion: 2008-01
• Study Completion: 2008-03
• Status Verified: 2008-09
• Study First Submitted: 2008-09-22
• Study First Submitted QC: 2008-09-22
• Study First Posted: 2008-09-23
• Last Update Submitted: 2008-12-17
• Last Update Posted: 2008-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Under clozapine with negative symptoms

Exclusion Criteria

• Pregnancy
• Lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	placebo	Clozapine plus placebo
2	memantine	Clozapine plus memantine

Primary Outcome Measures

Name	Time	Method
Score in Brief Psychiatric Raring Scale	baseline, 4 weeks, 8 weeks, 12 weeks

Trial Locations

Locations (1)

Hospital de Clinicas de Porto Alegre; 🇧🇷 Porto Alegre, RS, Brazil