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临床试验/NCT00963950
NCT00963950已完成不适用

Transvaginal Cholecystectomy

Yale University0 个研究点目标入组 30 人开始时间: 2009年8月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
30
主要终点
feasibility of transvaginal cholecystectomy

研究概览

简要总结

A safe and effective transvaginal approach accessing the abdominal cavity through the vagina rather than the abdominal wall is today considered a routine approach for many gynecologic surgeries.

First described by Dr. Ott in Germany in 1901, it is used routinely for transvaginal surgery, for example, transvaginal hysterectomies. This transvaginal technique has been shown to compare favorably to a laparoscopic abdominal approach because of less postoperative pain, the total elimination of abdominal wall hernias and wound infections, earlier recovery and better cosmesis.

Although routinely used in gynecological surgery, the advantages of the vaginal approach have not been utilized for general surgery applications such as cholecystectomies. Open or laparoscopic cholecystectomy accessing the abdominal cavity through abdominal wall incisions is currently still considered the standard of care in general surgery for patients with symptomatic gallbladder disease.

The investigators intend to access the abdominal cavity through the posterior vaginal fornix instead of the transabdominal approach that is now performed routinely. So far, this method of accessing the abdominal cavity through the transvaginal approach for the purpose of performing intraabdominal general surgery.

The investigators' transvaginal approach has the strong potential to further decrease invasiveness and take minimally invasive surgery to the next level in order to benefit the patient even more by minimizing postoperative pain, eliminating the risk of abdominal hernias and wound infections, improving cosmetic appearance and enabling the patient to return to routine activity and work earlier. First preliminary studies show these advantages but further research needs to be done to confirm these early positive results.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • Age between 18 and 65 years old.
  • Biliary dyskinesia with documented Gallbladder EF < 30% or diagnosis of biliary colic with documented gallstones or polyps by imaging.
  • Body Mass Index (BMI) < 45 kg/m2.

排除标准

  • Any female patient, who is pregnant, suspected pregnant, or lactating.
  • Any patient with acute or acalculous cholecystitis.
  • Any patient with an American Society of Anesthesiologists Score >
  • Any patient who is undergoing Peritoneal Dialysis (PD).
  • Patients who are taking immunosuppressive medications or are immunocompromised.
  • Patients on blood thinners or aspirin or abnormal blood coagulation tests.
  • Patients who have a history of prior open abdominal surgery or prior transvaginal surgery.
  • Patients with a history of ectopic pregnancy, pelvic inflammatory disease (PID) or severe endometriosis.
  • Non English speaking patients.

结局指标

主要结局

feasibility of transvaginal cholecystectomy

时间窗: 2 year

次要结局

  • quality of life(2 years)
  • pain(2 years)

研究者

申办方类型
Other
责任方
Sponsor

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